dissertation topics in medical biotechnology

200+ Biotechnology Research Topics: Let’s Shape the Future

In the dynamic landscape of scientific exploration, biotechnology stands at the forefront, revolutionizing the way we approach healthcare, agriculture, and environmental sustainability. This interdisciplinary field encompasses a vast array of research topics that hold the potential to reshape our world.

In this blog post, we will delve into the realm of biotechnology research topics, understanding their significance and exploring the diverse avenues that researchers are actively investigating.

Overview of Biotechnology Research

Table of Contents

Biotechnology, at its core, involves the application of biological systems, organisms, or derivatives to develop technologies and products for the benefit of humanity.

The scope of biotechnology research is broad, covering areas such as genetic engineering, biomedical engineering, environmental biotechnology, and industrial biotechnology. Its interdisciplinary nature makes it a melting pot of ideas and innovations, pushing the boundaries of what is possible.

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How to Select The Best Biotechnology Research Topics?

Identify Your Interests

Start by reflecting on your own interests within the broad field of biotechnology. What aspects of biotechnology excite you the most? Identifying your passion will make the research process more engaging.

Stay Informed About Current Trends

Keep up with the latest developments and trends in biotechnology. Subscribe to scientific journals, attend conferences, and follow reputable websites to stay informed about cutting-edge research. This will help you identify gaps in knowledge or areas where advancements are needed.

Consider Societal Impact

Evaluate the potential societal impact of your chosen research topic. How does it contribute to solving real-world problems? Biotechnology has applications in healthcare, agriculture, environmental conservation, and more. Choose a topic that aligns with the broader goal of improving quality of life or addressing global challenges.

Assess Feasibility and Resources

Evaluate the feasibility of your research topic. Consider the availability of resources, including laboratory equipment, funding, and expertise. A well-defined and achievable research plan will increase the likelihood of successful outcomes.

Explore Innovation Opportunities

Look for opportunities to contribute to innovation within the field. Consider topics that push the boundaries of current knowledge, introduce novel methodologies, or explore interdisciplinary approaches. Innovation often leads to groundbreaking discoveries.

Consult with Mentors and Peers

Seek guidance from mentors, professors, or colleagues who have expertise in biotechnology. Discuss your research interests with them and gather insights. They can provide valuable advice on the feasibility and significance of your chosen topic.

Balance Specificity and Breadth

Strike a balance between biotechnology research topics that are specific enough to address a particular aspect of biotechnology and broad enough to allow for meaningful research. A topic that is too narrow may limit your research scope, while one that is too broad may lack focus.

Consider Ethical Implications

Be mindful of the ethical implications of your research. Biotechnology, especially areas like genetic engineering, can raise ethical concerns. Ensure that your chosen topic aligns with ethical standards and consider how your research may impact society.

Evaluate Industry Relevance

Consider the relevance of your research topic to the biotechnology industry. Industry-relevant research has the potential for practical applications and may attract funding and collaboration opportunities.

Stay Flexible and Open-Minded

Be open to refining or adjusting your research topic as you delve deeper into the literature and gather more information. Flexibility is key to adapting to new insights and developments in the field.

200+ Biotechnology Research Topics: Category-Wise

Genetic engineering.

CRISPR-Cas9: Recent Advances and Applications
Gene Editing for Therapeutic Purposes: Opportunities and Challenges
Precision Medicine and Personalized Genomic Therapies
Genome Sequencing Technologies: Current State and Future Prospects
Synthetic Biology: Engineering New Life Forms
Genetic Modification of Crops for Improved Yield and Resistance
Ethical Considerations in Human Genetic Engineering
Gene Therapy for Neurological Disorders
Epigenetics: Understanding the Role of Gene Regulation
CRISPR in Agriculture: Enhancing Crop Traits

Biomedical Engineering

Tissue Engineering: Creating Organs in the Lab
3D Printing in Biomedical Applications
Advances in Drug Delivery Systems
Nanotechnology in Medicine: Theranostic Approaches
Bioinformatics and Computational Biology in Biomedicine
Wearable Biomedical Devices for Health Monitoring
Stem Cell Research and Regenerative Medicine
Precision Oncology: Tailoring Cancer Treatments
Biomaterials for Biomedical Applications
Biomechanics in Biomedical Engineering

Environmental Biotechnology

Bioremediation of Polluted Environments
Waste-to-Energy Technologies: Turning Trash into Power
Sustainable Agriculture Practices Using Biotechnology
Bioaugmentation in Wastewater Treatment
Microbial Fuel Cells: Harnessing Microorganisms for Energy
Biotechnology in Conservation Biology
Phytoremediation: Plants as Environmental Cleanup Agents
Aquaponics: Integration of Aquaculture and Hydroponics
Biodiversity Monitoring Using DNA Barcoding
Algal Biofuels: A Sustainable Energy Source

Industrial Biotechnology

Enzyme Engineering for Industrial Applications
Bioprocessing and Bio-manufacturing Innovations
Industrial Applications of Microbial Biotechnology
Bio-based Materials: Eco-friendly Alternatives
Synthetic Biology for Industrial Processes
Metabolic Engineering for Chemical Production
Industrial Fermentation: Optimization and Scale-up
Biocatalysis in Pharmaceutical Industry
Advanced Bioprocess Monitoring and Control
Green Chemistry: Sustainable Practices in Industry

Emerging Trends in Biotechnology

CRISPR-Based Diagnostics: A New Era in Disease Detection
Neurobiotechnology: Advancements in Brain-Computer Interfaces
Advances in Nanotechnology for Healthcare
Computational Biology: Modeling Biological Systems
Organoids: Miniature Organs for Drug Testing
Genome Editing in Non-Human Organisms
Biotechnology and the Internet of Things (IoT)
Exosome-based Therapeutics: Potential Applications
Biohybrid Systems: Integrating Living and Artificial Components
Metagenomics: Exploring Microbial Communities

Ethical and Social Implications

Ethical Considerations in CRISPR-Based Gene Editing
Privacy Concerns in Personal Genomic Data Sharing
Biotechnology and Social Equity: Bridging the Gap
Dual-Use Dilemmas in Biotechnological Research
Informed Consent in Genetic Testing and Research
Accessibility of Biotechnological Therapies: Global Perspectives
Human Enhancement Technologies: Ethical Perspectives
Biotechnology and Cultural Perspectives on Genetic Modification
Social Impact Assessment of Biotechnological Interventions
Intellectual Property Rights in Biotechnology

Computational Biology and Bioinformatics

Machine Learning in Biomedical Data Analysis
Network Biology: Understanding Biological Systems
Structural Bioinformatics: Predicting Protein Structures
Data Mining in Genomics and Proteomics
Systems Biology Approaches in Biotechnology
Comparative Genomics: Evolutionary Insights
Bioinformatics Tools for Drug Discovery
Cloud Computing in Biomedical Research
Artificial Intelligence in Diagnostics and Treatment
Computational Approaches to Vaccine Design

Health and Medicine

Vaccines and Immunotherapy: Advancements in Disease Prevention
CRISPR-Based Therapies for Genetic Disorders
Infectious Disease Diagnostics Using Biotechnology
Telemedicine and Biotechnology Integration
Biotechnology in Rare Disease Research
Gut Microbiome and Human Health
Precision Nutrition: Personalized Diets Using Biotechnology
Biotechnology Approaches to Combat Antibiotic Resistance
Point-of-Care Diagnostics for Global Health
Biotechnology in Aging Research and Longevity

Agricultural Biotechnology

CRISPR and Gene Editing in Crop Improvement
Precision Agriculture: Integrating Technology for Crop Management
Biotechnology Solutions for Food Security
RNA Interference in Pest Control
Vertical Farming and Biotechnology
Plant-Microbe Interactions for Sustainable Agriculture
Biofortification: Enhancing Nutritional Content in Crops
Smart Farming Technologies and Biotechnology
Precision Livestock Farming Using Biotechnological Tools
Drought-Tolerant Crops: Biotechnological Approaches

Biotechnology and Education

Integrating Biotechnology into STEM Education
Virtual Labs in Biotechnology Teaching
Biotechnology Outreach Programs for Schools
Online Courses in Biotechnology: Accessibility and Quality
Hands-on Biotechnology Experiments for Students
Bioethics Education in Biotechnology Programs
Role of Internships in Biotechnology Education
Collaborative Learning in Biotechnology Classrooms
Biotechnology Education for Non-Science Majors
Addressing Gender Disparities in Biotechnology Education

Funding and Policy

Government Funding Initiatives for Biotechnology Research
Private Sector Investment in Biotechnology Ventures
Impact of Intellectual Property Policies on Biotechnology
Ethical Guidelines for Biotechnological Research
Public-Private Partnerships in Biotechnology
Regulatory Frameworks for Gene Editing Technologies
Biotechnology and Global Health Policy
Biotechnology Diplomacy: International Collaboration
Funding Challenges in Biotechnology Startups
Role of Nonprofit Organizations in Biotechnological Research

Biotechnology and the Environment

Biotechnology for Air Pollution Control
Microbial Sensors for Environmental Monitoring
Remote Sensing in Environmental Biotechnology
Climate Change Mitigation Using Biotechnology
Circular Economy and Biotechnological Innovations
Marine Biotechnology for Ocean Conservation
Bio-inspired Design for Environmental Solutions
Ecological Restoration Using Biotechnological Approaches
Impact of Biotechnology on Biodiversity
Biotechnology and Sustainable Urban Development

Biosecurity and Biosafety

Biosecurity Measures in Biotechnology Laboratories
Dual-Use Research and Ethical Considerations
Global Collaboration for Biosafety in Biotechnology
Security Risks in Gene Editing Technologies
Surveillance Technologies in Biotechnological Research
Biosecurity Education for Biotechnology Professionals
Risk Assessment in Biotechnology Research
Bioethics in Biodefense Research
Biotechnology and National Security
Public Awareness and Biosecurity in Biotechnology

Industry Applications

Biotechnology in the Pharmaceutical Industry
Bioprocessing Innovations for Drug Production
Industrial Enzymes and Their Applications
Biotechnology in Food and Beverage Production
Applications of Synthetic Biology in Industry
Biotechnology in Textile Manufacturing
Cosmetic and Personal Care Biotechnology
Biotechnological Approaches in Renewable Energy
Advanced Materials Production Using Biotechnology
Biotechnology in the Automotive Industry

Miscellaneous Topics

DNA Barcoding in Species Identification
Bioart: The Intersection of Biology and Art
Biotechnology in Forensic Science
Using Biotechnology to Preserve Cultural Heritage
Biohacking: DIY Biology and Citizen Science
Microbiome Engineering for Human Health
Environmental DNA (eDNA) for Biodiversity Monitoring
Biotechnology and Astrobiology: Searching for Life Beyond Earth
Biotechnology and Sports Science
Biotechnology and the Future of Space Exploration

Challenges and Ethical Considerations in Biotechnology Research

As biotechnology continues to advance, it brings forth a set of challenges and ethical considerations. Biosecurity concerns, especially in the context of gene editing technologies, raise questions about the responsible use of powerful tools like CRISPR.

Ethical implications of genetic manipulation, such as the creation of designer babies, demand careful consideration and international collaboration to establish guidelines and regulations.

Moreover, the environmental and social impact of biotechnological interventions must be thoroughly assessed to ensure responsible and sustainable practices.

Funding and Resources for Biotechnology Research

The pursuit of biotechnology research topics requires substantial funding and resources. Government grants and funding agencies play a pivotal role in supporting research initiatives.

Simultaneously, the private sector, including biotechnology companies and venture capitalists, invest in promising projects. Collaboration and partnerships between academia, industry, and nonprofit organizations further amplify the impact of biotechnological research.

Future Prospects of Biotechnology Research

As we look to the future, the integration of biotechnology with other scientific disciplines holds immense potential. Collaborations with fields like artificial intelligence, materials science, and robotics may lead to unprecedented breakthroughs.

The development of innovative technologies and their application to global health and sustainability challenges will likely shape the future of biotechnology.

In conclusion, biotechnology research is a dynamic and transformative force with the potential to revolutionize multiple facets of our lives. The exploration of diverse biotechnology research topics, from genetic engineering to emerging trends like synthetic biology and nanobiotechnology, highlights the breadth of possibilities within this field.

However, researchers must navigate challenges and ethical considerations to ensure that biotechnological advancements are used responsibly for the betterment of society.

With continued funding, collaboration, and a commitment to ethical practices, the future of biotechnology research holds exciting promise, propelling us towards a more sustainable and technologically advanced world.

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Introduction

Modern biotechnology has been credited with breakthrough innovations in the field of product development and technologies to help us develop a cleaner and more sustainable world. It is primarily because of biotechnology; we have progressed towards the development of more efficient industrial manufacturing base. Besides, it is helping in the production of cleaner energy, feed more hungry people without leaving much of our environmental footprint, and help mankind combat rare and debilitating diseases.

Our assignment writing services in the field of biotechnology cover all types of subject topics that test and vindicate the skill sets of the students before awarding them with their respective degrees. We help students successfully pass their syllabus in all forms of biotechnology courses. These include medical biotechnology (red), environmental biotechnology (green), marine biotechnology (blue) and industrial biotechnology (white).

What are We Expecting to Gain from All these Efforts?

Our sole objective of preparing this marathon list of top 100 biotechnology assignment topics is to help students decide upon effective time management skills. We have seen an immense numbers of cases where while exploring online assignment help related to topic selection, exploration of information sources, and citing them in correct reference order, students get stuck at different stages. Amongst them, most of the students find it difficult even to pass their topic selection dilemma. That is where we contribute to our efforts to make things easy for the biotech students right in one go. We help our students save time and energy, so that they can prudently use the assigned time to prepare the content of their assignment around the best topics.

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Must read: wish to master dissertation skills in 2 weeks learn from the experts here, top 100 biotechnology dissertation topics trending in the year 2021.

We have prepared the list of top 100 most recommended dissertation topics prepared by our research experts. They have ensured to provide a comprehensive list of topics that are covering all the dimensions of the subject. We fully hope that the list would cover all your dissertation help requirements. So, let us begin with the prepared list of topics one by one –

Effective management of renewable energy technology to promote a village
The production of ethanol with the help of molasses as well as its effluent treatment
Different methods and aspects of evapotranspiration
The scattering parameters of the circulator biotechnology
The inactivation of the mammalian TLR2 through an inhibiting antibody
Number of proteins through Mycobacterium tuberculosis
The recognition and classification of the genes shaping the plant responses to salinity and drought
The segment of small signing molecules in the responses of plants to salinity and drought
Genetic improvement of the plant lenience to salinity and drought
Pharmacogenomics of the drug transporters
Pharmacogenomics of the anti-cancer drugs
Pharmacogenomics of the anti-hypertensive drugs
Indels genotyping of the African populations
Y-chromosome genotyping of the African populations
Profiling of the DNA isolated from the historical crime scenes: Discuss in terms of South African Innocence Project
Nanotechnology methods in terms of DNA isolation
Nanotechnology applications in terms of DNA genotyping
Recognizing heavy metal tolerant along with sensitive genotypes
Features of genes that participate in the process of heavy metal tolerance
DNA authentication of the animal species through raw meat products reared commercially
Molecular based technology in terms of rapid identification and detection of the food borne pathogens with respect to complex food systems
Making an assessment of cancer specific peptides for successful implementations in the field of cancer diagnosis
Quantum dot-based detection system development with respect to successful breast cancer diagnosis
Targeted delivery of the embelin to the cancer cells
Accessing the role of novel quinone compounds to perform as anti-cancer agents
Therapeutic approaches to the treatment of HIV and the role of nanotechnology in it
An assessment of the medicinal value of the natural antioxidants
An indepth study of the structure of the COVID spike proteins
An assessment of the immune response of the stem cell therapy
The use of CRISPR-Cas9 technology for the purpose of genome editing
Tissue engineering and the drug delivery with the application of Chitosan
An assessment of therapeutic effects of the cancer vaccines
Utilization of PacBio sequencing with respect to genome assembly of the model organisms
Studying the relationship between the mRNA suppression and its impact on the expansion of the stem cell
Utilizing biomimicry for the identification of the tumor cells
The sub-classification and characterization of the Yellow enzymes
The production of the hypoallergenic fermented foods
The production of the hypoallergenic milk
The purification process of the thermostable phytase
Bioconversion of the cellulose to successfully yield the products that are industrially significant
The examination of the gut microbiota in the model organisms
The utilization of the fungal enzymes in the production of chemical glue
An examination of the inhibitors of exocellulase and endocellulase
Discuss the utility of microorganisms in the recovery of shale gas
Discuss the in-depth study of the procedure of natural decomposition
Discuss the process of recycling the bio-wastes
Enhanced bio-remediation for the cases of oil spills
The process of gold biosorption with the help of cyanobacterium
Maintaining a healthy balance between the biotic and the abiotic factors with the help of biotechnological tools
Labeling the level of mercury in fish with the help of markers
Exploring out the biotechnological potential of the Jellyfish related microbiome
What is the potential of marine fungi in the efforts to degrade polymers and plastics?
Discuss the biotechnological potential that one can fetch out of dinoflagellates
Tracing out endosulfan residues with the application of biotechnology in the field of agricultural products
The development of the ELISA technique for the identification of crop viruses
Boosting the quality of drinking water with the help of E.coli consortium
The characterization of E.coli isolation from the feces of the zoo animals
Improving the resistance of the crops against the invasion of the insects
Reducing the spending on agriculture with the help of effective bio-tools
What are the most effective steps to reduce soil erosion with the utility of tools derived from biotechnology?
How biotechnology can help in the improvement the levels of vitamin in GM foods?
Improving the delivery of pesticide with the help of biotechnology
Comparing folate biofortification in different kinds of corps
Discuss the photovoltaic-based production of the ocean crops
How the application of nanotechnology to improve the activities of the agricultural sector?
Examining the mechanisms of water stress tolerance in the model plants
Testing and production of the human immune boosters in the experimental organisms
Comparing genomic analysis with the utility of tools meant for bioinformatics
Arabinogalactan protein sequencing and its utility in computational methods
Evaluating and interpreting gut microbiota in the model organisms
Different techniques of protein purification: A comparative analysis
Diagnosing microbes and their role in o ligonucleotide micro-arrays
The application of different techniques in the field of biomedical research comprising micro-arrays technology
The application of microbial consortium in producing the greenhouse effect
Computational assessment of various proteins accessed from marine microbiota
E.coli gene mapping with the application of various microbial tools
Enhancing the strains of cyanobacterium with the help of gene sequencing
Computational assessment and description of the crystallized proteins present in nature
mTERF protein and its application to terminate the transcription of mitochondrial DNA in algae
Reverse phase column chromatography and its application in separating proteins
The study of various proteins present within Mycobacterium leprae
An assessment of the strategies that are ideally suitable for successful cloning of RNA
Discuss the common failures of biotechnology in saving the ecology and the environment
Is there a way to make the medicinal plants free of pests? Discuss
What are the harms imposed by pest resistant corps on humans and birds?
What are the diverse fields of biotechnology that still remain unexplored in terms of research?
What is the future of biotechnology in the field of medicine?
The application of recombinant DNA technology in the invention of new forms of medicine
Why is the strain of bacteria used to create vaccine with the help of biotechnology?
How biotechnology can help in the creation of medicines that are more resistant towards the mutating forms of viruses and bacteria?
Can there be a permanent cure for cancer in the future? How biotechnology can play a decisive role in it?
Why it is critical for the students to effectively remember the DNA coding in the field of biotechnology?
How one can make hybrid seeds with the help from biotechnology?
How one can generate pest resistant seeds and what are their benefits in the end yielding in agriculture?
Discuss bio-magnification and its impact on ecology
What are the reasons due to which the ecologists disapprove the usage of pest resistant seeds, despite their usage in the field of agriculture?
How biotechnology positively influenced the lives of farmers in the developing economies?
How biotechnology functions to increase in yield of the crop plants?
Discuss the role of biotechnology in boosting the output of seasonal crops
Are there adverse effects of medicines in pharmacology when manufactured with biotechnological principles? Throw some light on the question with real-life cases

Now with that, we have reached the end of this list and fully hope that it would have served the purpose of topic selection requirements. Besides, the inclusion of biotechnology assignment topics has been done in such a manner that it can help us out with our needs related to different other assignment writing formats as well. For instance, all our topic selection requirements related to case study help , essay help , research paper writing help or thesis help can also be met with the topics in the above-mentioned list.

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Must read: top 100 biology dissertation topics for the year 2021.

Biotechnology is a subject that is meant to offer a plethora of research prospects. A successful completion of course in one or more streams of biotechnology will ensure job placement opportunities in different research and development companies dedicated to the field. The objective of recommending this list is to help you make the right topic selection in less amount of time and dedicate more time to assignment research, and adequate content writing. After all, going an extra mile in terms of efforts will ensure that the final submission is good enough to help you earn the grades that can help you beat the competition.

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1. Gene Editing and Genomic Engineering

an artist s illustration of artificial intelligence ai this image depicts how ai could assist in genomic studies and its applications it was created by artist nidia dias as part of the

a. CRISPR and Gene Editing

Precision Medicine : Developing targeted therapies for various diseases using CRISPR/Cas9 and other gene-editing tools.

Ethical Implications : Exploring and addressing ethical concerns surrounding CRISPR use in human embryos and germline editing.

Agricultural Advancements : Enhancing crop resistance and nutritional content through gene editing of improved farm outcomes.

Gene Drive Technology : Investigating the potential of gene drive technology to control vector-borne diseases like malaria and dengue fever.

Regulatory Frameworks : Establishing global regulations for responsible gene editing applications in different fields.

b. Synthetic Biology

Bioengineering Microbes : Creating engineered microorganisms for sustainable production of fuels, pharmaceuticals, and materials.

Designer Organisms : Designing novel organisms with specific functionalities for environmental remediation or industrial processes.

Cell-Free Systems : Developing cell-free systems for various applications, including drug production and biosensors.

Biosecurity Measures : Addressing concerns regarding the potential misuse of synthetic biology for bioterrorism.

Standardization and Automation : Standardizing synthetic biology methodologies and automating processes to streamline production.

2. Personalized Medicine and Pharmacogenomics

a. Precision Medicine

Individualized Treatment : Tailoring medical treatment based on a person’s genetic makeup and environmental factors.

Cancer Therapy : Advancing targeted cancer therapies based on the genetic profile of tumors and patients.

Data Analytics : Implementing big data and AI for comprehensive analysis of genomic and clinical data to improve treatment outcomes.

Clinical Implementation : Integrating genetic testing into routine clinical practice for personalized healthcare.

Public Health and Policy : Addressing the challenges of integrating personalized medicine into public health policies and practices.

b. Pharmacogenomics

Drug Development : Optimizing drug development based on individual genetic variations to improve efficacy and reduce side effects.

Adverse Drug Reactions : Understanding genetic predispositions to adverse drug reactions and minimizing risks.

Dosing Optimization : Tailoring drug dosage based on an individual’s genetic profile for better treatment outcomes.

Economic Implications : Assessing the economic impact of pharmacogenomics on healthcare systems.

Education and Training : Educating healthcare professionals on integrating pharmacogenomic data into clinical practice.

3. Nanobiotechnology and Nanomedicine

a. Nanoparticles in Medicine

Drug Delivery Systems : Developing targeted drug delivery systems using nanoparticles for enhanced efficacy and reduced side effects.

Theranostics : Integrating diagnostics and therapeutics through nanomaterials for personalized medicine.

Imaging Techniques : Advancing imaging technologies using nanoparticles for better resolution and early disease detection.

Biocompatibility and Safety : Ensuring the safety and biocompatibility of nanoparticles used in medicine.

Regulatory Frameworks : Establishing regulations for the use of nanomaterials in medical applications.

b. Nanosensors and Diagnostics

Point-of-Care Diagnostics : Developing portable and rapid diagnostic tools for various diseases using nanotechnology.

Biosensors : Creating highly sensitive biosensors for detecting biomarkers and pathogens in healthcare and environmental monitoring.

Wearable Health Monitors : Integrating nanosensors into wearable devices for continuous health monitoring.

Challenges and Limitations : Addressing challenges in scalability, reproducibility, and cost-effectiveness of nanosensor technologies.

Future Applications : Exploring potential applications of nanosensors beyond healthcare, such as environmental monitoring and food safety.

4. Immunotherapy and Vaccine Development

person holding syringe and vaccine bottle

a. Cancer Immunotherapy

Immune Checkpoint Inhibitors : Enhancing the efficacy of immune checkpoint inhibitors and understanding resistance mechanisms.

CAR-T Cell Therapy : Improving CAR-T cell therapy for a wider range of cancers and reducing associated side effects.

Combination Therapies : Investigating combination therapies for better outcomes in cancer treatment.

Biomarkers and Predictive Models : Identifying predictive biomarkers for immunotherapy response.

Long-Term Effects : Studying the long-term effects and immune-related adverse events of immunotherapies.

b. Vaccine Technology

mRNA Vaccines : Advancing mRNA vaccine technology for various infectious diseases and cancers.

Universal Vaccines : Developing universal vaccines targeting multiple strains of viruses and bacteria.

Vaccine Delivery Systems : Innovating vaccine delivery methods for improved stability and efficacy.

Vaccine Hesitancy : Addressing vaccine hesitancy through education, communication, and community engagement.

Pandemic Preparedness : Developing strategies for rapid vaccine development and deployment during global health crises.

5. Environmental Biotechnology and Sustainability

a. Bioremediation and Bioenergy

Biodegradation Techniques : Using biotechnology to enhance the degradation of pollutants and contaminants in the environment.

Biofuels : Developing sustainable biofuel production methods from renewable resources.

Microbial Fuel Cells : Harnessing microbial fuel cells for energy generation from organic waste.

Circular Economy : Integrating biotechnological solutions for a circular economy and waste management.

Ecosystem Restoration : Using biotechnology for the restoration of ecosystems affected by pollution and climate change.

b. Agricultural Biotechnology

Genetically Modified Crops : Advancing genetically modified crops for improved yields, pest resistance, and nutritional content.

Precision Agriculture : Implementing biotechnological tools for precise and sustainable farming practices.

Climate-Resilient Crops : Developing crops resilient to climate change-induced stresses.

Micro-biome Applications : Leveraging the plant micro-biome for enhanced crop health and productivity.

Consumer Acceptance and Regulation : Addressing consumer concerns and regulatory challenges related to genetically modified crops.

The field of biotechnology is a beacon of hope for addressing the challenges of our time, offering promising solutions for healthcare, sustainability, and more. As researchers explore these emerging topics, the potential for ground-breaking discoveries and transformative applications is immense.

I hope this article will help you to find the top research topics in biotechnology that promise to revolutionize healthcare, agriculture, environmental sustainability, and more.

Drug delivery
Environmental Engineering
Gene editing
Genomic Engineering
Molecular Biology
Nanoparticles
Pharmacogenomics
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45 Biomedical Research Topics for You

Although choosing relevant biomedical research topics is often an arduous task for many, it shouldn’t be for you. You no longer have to worry as we have provided you with a list of topics in biomedical science in this write-up.

Biomedical research is a broad aspect of science, and it is still evolving. This aspect of science involves a variety of ways to prevent and treat diseases that lead to illness and death in people.

This article contains 45 biomedical topics. The topics were carefully selected to guide you in choosing the right topics. They can be used for presentations, seminars, or research purposes, as the case may be.

So, suppose you need topics in biomedical ethics for papers or biomedical thesis topics for various purposes. In that case, you absolutely have to keep reading! Are you ready to see our list of biomedical topics? Then, let’s roll.

Biomedical Engineering Research Topics

Biomedical engineering is the branch of engineering that deals with providing solutions to problems in medicine and biology. Biomedical engineering research is an advanced area of research. Are you considering taking up research in this direction?

Research topics in this area cannot just be coined while eating pizza. It takes a lot of hard work to think out something meaningful. However, we have made a list for you! Here is a list of biomedical engineering topics!

How to apply deep learning in biomedical engineering
Bionics: the latest discoveries and applications
The techniques of genetic engineering
The relevance of medical engineering today
How environmental engineering has affected the world

Biomedical Ethics Topics

There are ethical issues surrounding healthcare delivery, research, biotechnology, and medicine. Biomedical Ethics is fundamental to successful practice experience and is addressed by various disciplines. If you want to research this area, then you do not have to look for topics. Here’s a list of biomedical ethics for paper that you can choose from:

The fundamentals of a physician-patient relationship
How to handle disability issues as a health care sector
Resource allocation and distribution
All you need to know about coercion, consent, and or vulnerability
Ethical treatment of subjects or animals in clinical trials

Relevant Biomedical Topics

Topics in Biomedical science are numerous, but not all are relevant today. Since biomedical science is constantly evolving, newer topics are coming up. If you desire in your topic selection, read on. Here is a list of relevant biomedical topics just for you!

The replacement of gene therapy by gene editing
Revolution of vaccine development by synthetic biology
Introduction of artificial blood – the impact on the health sector
Ten things know about artificial womb
Transplanted reproductive organs and transgender birth

Biomedical Science Topics

Biomedical science is the aspect of scientific studies that focuses on applying biology and chemistry to health care. This field of science has a broad range of disciplines. If you intend to do research in this field, look at this list of research topics in biomedical science.

The role of biomechanics in health care delivery
Importance of biomaterials and regeneration engineering
The application of cell and molecular engineering to medicine
The evolution of medical instrumentation and devices
Neural engineering- the latest discoveries

Seminar Topics for Biomedical Instrumentation

Biomedical science is constantly making progress, especially in the aspect of biomedical instrumentation. This makes it worthy of a seminar presentation in schools where it is taught. However, choosing a biomedical research topic for a biomedical instrumentation seminar may not come easy. This is why we have collated five brilliant topics for biomedical instrumentation just for you. They include:

Microelectrode in neuro-transplants
Hyperbaric chamber for oxygen therapy
How concentric ring electrodes can be used to manage epilepsy
How electromagnetic interference makes cochlear implants work
Neuroprosthetics Management using Brain-computer interfaces (BCI)

Biomedical Engineering Topics for Presentation

One of the interesting aspects of biomedical science in biomedical engineering. It is the backbone that gives the biomedical science structure. Are you interested in making presentations about biomedical engineering topics? Or do you need biomedical engineering topics for paper? Get started here! We have compiled a list of biomedical engineering topics for you. Here they are:

In-the-ear device to control stuttering: the basis of its operation
How to implement the magnetic navigated catheterization
Semiconductor-cell interfaces: the rudiments of its application
The benefits of tissue engineering of muscle
The benefits of sensitive artificial skin for prosthetic arms

Hot Topics in Biomedical Research

Biomedical research is fun because it is often relatable. As interesting as it seems, choosing a topic for research doesn’t come easy at all. Yet, there are also a lot of trending events around biomedical topics. To simplify your selection process, we have written out a few of them here.

Here are some hot biomedical research topics below.

What is immunology, and what is the relevance today?
Regenerative medicine- definition, importance, and application
Myths about antibiotic resistance
Vaccine development for COVID-19
Infectious diseases now and before

Biomedical Research Topics

Biomedical research is an extensive process. It requires a lot of time, dedication, and resources. Getting a topic shouldn’t be added to that list. There are biomedical thesis topics and research topics in biomedical science for you here:

Air pollution- sources, impact, and prevention
Covid-19 vaccination- the effect on life expectancy
Hyper insomnia- what is responsible?
Alzheimer’s disease- newer treatment approaches
Introduction of MRI compatible infusion pump

Biomedical Nanotechnology Topics

Biomedical research topics and areas now include nanotechnology. Nanotechnology has extended its tentacles to medicine and has been used to treat cancer successfully. This makes it a good research area. It is good for seminar presentations. Here are some biomedical nanotechnology topics below.

The uses of functional particles and nanomaterials
Nanoparticles based drug delivery system
The incorporation of nanoporous membranes into biomedical devices
Nanostructured materials for biological sensing
Nanocrystals- imaging, transportation, and toxicity features

Seeking professional assistance to write your biomedical research or thesis? Look no further! At our reputable writing service, our experienced writers specialize in providing tailored support for the complexities of biomedical research. When you say, “ do my thesis for me ” we’re here to guide you through formulating research questions, conducting literature reviews, and analyzing data sets. Entrust the writing process to our experts while you focus on exploring the frontiers of biomedical research. Contact us today for a meticulously crafted thesis that enhances your chances of success.

We believe you have been thoroughly equipped with a list of biomedical topics. This way, you wouldn’t have to go through the stress of choosing a topic for research, seminars, or other educational purposes. Now that you have the topics at your fingertips make your choice and enjoy!

Frequently Asked Questions

Richard Ginger is a dissertation writer and freelance columnist with a wealth of knowledge and expertise in the writing industry. He handles every project he works on with precision while keeping attention to details and ensuring that every work he does is unique.

dissertation topics in medical biotechnology

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Biotechnology

Research in biotechnology can helps in bringing massive changes in humankind and lead to a better life. In the last few years, there have been so many leaps, and paces of innovations as scientists worldwide worked to develop and produce novel mRNA vaccinations and brought some significant developments in biotechnology. During this period, they also faced many challenges. Disturbances in the supply chain and the pandemic significantly impacted biotech labs and researchers, forcing lab managers to become ingenious in buying lab supplies, planning experiments, and using technology for maintaining research schedules.

The Biotech Research Technique is changing

How research is being done is changing, as also how scientists are conducting it. Affected by both B2C eCommerce and growing independence in remote and cloud-dependent working, most of the biotechnology labs are going through some digital transformations. This implies more software, automation, and AI in the biotech lab, along with some latest digital procurement plans and integrated systems for various lab operations.

Look at some of the top trends in biotech research and recent Biotechnology Topics that are bringing massive changes in this vast world of science, resulting in some innovation in life sciences and biotechnology ideas .

We share different job or exam notices on Labmonk Notice Board . You can search “ Labmonk Notice Board ” on google search to check out latest jobs of your field.

Research Topics & Ideas

Biotechnology and Genetic Engineering

If you’re just starting out exploring biotechnology-related topics for your dissertation, thesis or research project, you’ve come to the right place. In this post, we’ll help kickstart your research topic ideation process by providing a hearty list of research topics and ideas , including examples from recent studies.

PS – This is just the start…

We know it’s exciting to run through a list of research topics, but please keep in mind that this list is just a starting point . To develop a suitable research topic, you’ll need to identify a clear and convincing research gap , and a viable plan to fill that gap.

If this sounds foreign to you, check out our free research topic webinar that explores how to find and refine a high-quality research topic, from scratch. Alternatively, if you’d like hands-on help, consider our 1-on-1 coaching service .

Biotechnology Research Topic Ideas

Below you’ll find a list of biotech and genetic engineering-related research topics ideas. These are intentionally broad and generic , so keep in mind that you will need to refine them a little. Nevertheless, they should inspire some ideas for your project.

Developing CRISPR-Cas9 gene editing techniques for treating inherited blood disorders.
The use of biotechnology in developing drought-resistant crop varieties.
The role of genetic engineering in enhancing biofuel production efficiency.
Investigating the potential of stem cell therapy in regenerative medicine for spinal cord injuries.
Developing gene therapy approaches for the treatment of rare genetic diseases.
The application of biotechnology in creating biodegradable plastics from plant materials.
The use of gene editing to enhance nutritional content in staple crops.
Investigating the potential of microbiome engineering in treating gastrointestinal diseases.
The role of genetic engineering in vaccine development, with a focus on mRNA vaccines.
Biotechnological approaches to combat antibiotic-resistant bacteria.
Developing genetically engineered organisms for bioremediation of polluted environments.
The use of gene editing to create hypoallergenic food products.
Investigating the role of epigenetics in cancer development and therapy.
The application of biotechnology in developing rapid diagnostic tools for infectious diseases.
Genetic engineering for the production of synthetic spider silk for industrial use.
Biotechnological strategies for improving animal health and productivity in agriculture.
The use of gene editing in creating organ donor animals compatible with human transplantation.
Developing algae-based bioreactors for carbon capture and biofuel production.
The role of biotechnology in enhancing the shelf life and quality of fresh produce.
Investigating the ethics and social implications of human gene editing technologies.
The use of CRISPR technology in creating models for neurodegenerative diseases.
Biotechnological approaches for the production of high-value pharmaceutical compounds.
The application of genetic engineering in developing pest-resistant crops.
Investigating the potential of gene therapy in treating autoimmune diseases.
Developing biotechnological methods for producing environmentally friendly dyes.

Biotech & GE Research Topic Ideas (Continued)

The use of genetic engineering in enhancing the efficiency of photosynthesis in plants.
Biotechnological innovations in creating sustainable aquaculture practices.
The role of biotechnology in developing non-invasive prenatal genetic testing methods.
Genetic engineering for the development of novel enzymes for industrial applications.
Investigating the potential of xenotransplantation in addressing organ donor shortages.
The use of biotechnology in creating personalised cancer vaccines.
Developing gene editing tools for combating invasive species in ecosystems.
Biotechnological strategies for improving the nutritional quality of plant-based proteins.
The application of genetic engineering in enhancing the production of renewable energy sources.
Investigating the role of biotechnology in creating advanced wound care materials.
The use of CRISPR for targeted gene activation in regenerative medicine.
Biotechnological approaches to enhancing the sensory qualities of plant-based meat alternatives.
Genetic engineering for improving the efficiency of water use in agriculture.
The role of biotechnology in developing treatments for rare metabolic disorders.
Investigating the use of gene therapy in age-related macular degeneration.
The application of genetic engineering in developing allergen-free nuts.
Biotechnological innovations in the production of sustainable and eco-friendly textiles.
The use of gene editing in studying and treating sleep disorders.
Developing biotechnological solutions for the management of plastic waste.
The role of genetic engineering in enhancing the production of essential vitamins in crops.
Biotechnological approaches to the treatment of chronic pain conditions.
The use of gene therapy in treating muscular dystrophy.
Investigating the potential of biotechnology in reversing environmental degradation.
The application of genetic engineering in improving the shelf life of vaccines.
Biotechnological strategies for enhancing the efficiency of mineral extraction in mining.

Recent Biotech & GE-Related Studies

While the ideas we’ve presented above are a decent starting point for finding a research topic in biotech, they are fairly generic and non-specific. So, it helps to look at actual studies in the biotech space to see how this all comes together in practice.

Below, we’ve included a selection of recent studies to help refine your thinking. These are actual studies, so they can provide some useful insight as to what a research topic looks like in practice.

Genetic modifications associated with sustainability aspects for sustainable developments (Sharma et al., 2022)
Review On: Impact of Genetic Engineering in Biotic Stresses Resistance Crop Breeding (Abebe & Tafa, 2022)
Biorisk assessment of genetic engineering — lessons learned from teaching interdisciplinary courses on responsible conduct in the life sciences (Himmel et al., 2022)
Genetic Engineering Technologies for Improving Crop Yield and Quality (Ye et al., 2022)
Legal Aspects of Genetically Modified Food Product Safety for Health in Indonesia (Khamdi, 2022)
Innovative Teaching Practice and Exploration of Genetic Engineering Experiment (Jebur, 2022)
Efficient Bacterial Genome Engineering throughout the Central Dogma Using the Dual-Selection Marker tetAOPT (Bayer et al., 2022)
Gene engineering: its positive and negative effects (Makrushina & Klitsenko, 2022)
Advances of genetic engineering in streptococci and enterococci (Kurushima & Tomita, 2022)
Genetic Engineering of Immune Evasive Stem Cell-Derived Islets (Sackett et al., 2022)
Establishment of High-Efficiency Screening System for Gene Deletion in Fusarium venenatum TB01 (Tong et al., 2022)
Prospects of chloroplast metabolic engineering for developing nutrient-dense food crops (Tanwar et al., 2022)
Genetic research: legal and ethical aspects (Rustambekov et al., 2023). Non-transgenic Gene Modulation via Spray Delivery of Nucleic Acid/Peptide Complexes into Plant Nuclei and Chloroplasts (Thagun et al., 2022)
The role of genetic breeding in food security: A review (Sam et al., 2022). Biotechnology: use of available carbon sources on the planet to generate alternatives energy (Junior et al., 2022)
Biotechnology and biodiversity for the sustainable development of our society (Jaime, 2023) Role Of Biotechnology in Agriculture (Shringarpure, 2022)
Plants That Can be Used as Plant-Based Edible Vaccines; Current Situation and Recent Developments (İsmail, 2022)

As you can see, these research topics are a lot more focused than the generic topic ideas we presented earlier. So, in order for you to develop a high-quality research topic, you’ll need to get specific and laser-focused on a specific context with specific variables of interest. In the video below, we explore some other important things you’ll need to consider when crafting your research topic.

Get 1-On-1 Help

If you’re still unsure about how to find a quality research topic, check out our Research Topic Kickstarter service, which is the perfect starting point for developing a unique, well-justified research topic.

Research Topic Kickstarter - Need Help Finding A Research Topic?

i want to write a research concept for my scholarship now i don’t know how to write it. my study area of interest is Master of Science in molecular biology. my proposed research topics are

1. use of genetic engineering in developing climate change resilient crops. 2. biotechnology in farming; improving drought resistance, pest and disease control

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Research Proposal Topics In Biotechnology

Biotechnology is a fascinating subject that blends biology and technology and provides a huge chance to develop new ideas. However, before pursuing a career in this field, a person needs to complete a number of studies and have a thorough knowledge of the matter. When we begin our career must we conduct study to discover some innovative innovations that could benefit people around the world. Biotechnology is one of a variety of sciences of life, including pharmacy. Students who are pursuing graduation, post-graduation or PhD must complete the research work and compose their thesis to earn the satisfaction in their education. When choosing a subject for biotechnology-related research it is important to choose one that is likely to inspire us. Based on our passion and personal preferences, the subject to study may differ.

What is Biotechnology?

In its most basic sense, biotechnology is the science of biology that enables technology Biotechnology harnesses the power of the biomolecular and cellular processes to create products and technologies that enhance our lives and the wellbeing of the planet. Biotechnology has been utilizing microorganisms' biological processes for over six thousand years to create useful food items like cheese and bread as well as to keep dairy products in good condition.

Modern biotechnology has created breakthrough products and technology to treat rare and debilitating illnesses help reduce our footprint on the environment and feed hungry people, consume less energy and use less and provide safer, more clean and productive industrial production processes.

Introduction

Biotechnology is credited with groundbreaking advancements in technological development and development of products to create sustainable and cleaner world. This is in large part due to biotechnology that we've made progress toward the creation of more efficient industrial manufacturing bases. Additionally, it assists in the creation of greener energy, feeding more hungry people and not leaving a large environmental footprint, and helping humanity fight rare and fatal diseases.

Our writing services for assignments within the field of biotechnology covers all kinds of subjects that are designed to test and validate the skills of students prior to awarding their certificates. We assist students to successfully complete their course in all kinds of biotechnology-related courses. This includes biological sciences for medical use (red) and eco-biotechnology (green) marine biotechnology (blue) and industrial biotechnology (white).

What do we hope to gain from all these Initiatives?

Our primary goal in preparing this list of the top 100 biotechnology assignment subjects is to aid students in deciding on effective time management techniques. We've witnessed a large amount of cases where when looking for online help with assignments with the topic, examining sources of information, and citing the correct order of reference students find themselves stuck at various points. In the majority of cases, students have difficulty even to get through their dilemma of choosing a topic. This is why we contribute in our effort to help make the process easier for students in biotech quickly and efficiently. Our students are able to save time and energy in order to help them make use of the time they are given to write the assignment with the most appropriate topics.

Let's look at some of the newest areas of biotechnology research and the related areas.

Renewable Energy Technology Management Promoting Village
Molasses is a molasses-based ingredient that can be used to produce and the treatment of its effluent
Different ways to evapotranspirate
Scattering Parameters of Circulator Bio-Technology
Renewable Energy Technology Management Promoting Village.

Structural Biology of Infectious Diseases

A variety of studies are being conducted into the techniques used by pathogens in order to infect humans and other species and for designing strategies for countering the disease. The main areas that are available to study by biotech researchers include:

inlA from Listeria monocytogenes when combined with E-cadherin from humans.
InlC in Listeria monocytogenes that are multipart with human Tuba.
Phospholipase PatA of Legionella pnemophila.
The inactivation process of mammalian TLR2 by inhibiting antibody.
There are many proteins that come originate from Mycobacterium tuberculosis.

Plant Biotechnology

Another significant area for research in biotechnology for plants is to study the genetic causes of the plant's responses to scarcity and salinity, which have a significant impact on yields of the crop and food.

Recognition and classification of genes that influence the responses of plants to drought and salinity.
A component of small-signing molecules in plants' responses to salinity and drought.
Genetic enhancement of plant sensitivity salinity and drought.

Pharmacogenetics

It's also a significant area for conducting research in biotechnology. One of the most important reasons for doing so could be the identification of various genetic factors that cause differences in drug effectiveness and susceptibility for adverse reactions. Some of the subjects which can be studied are,

Pharmacogenomics of Drug Transporters
Pharmacogenomics of Metformin's response to type II mellitus
The pharmacogenomics behind anti-hypertensive medicines
The Pharmacogenomics of anti-cancer drugs

Forensic DNA

A further area of research in biotechnology research is the study of the genetic diversity of humans for its applications in criminal justice. Some of the topics that could be studied include,

Y-chromosome Forensic Kit, Development of commercial prototype.
Genetic testing of Indels in African populations.
The Y-chromosome genotyping process is used for African populations.
Study of paternal and maternal ancestry of mixed communities in South Africa.
The study of the local diversity in genetics using highly mutating Y-STRs and Indels.
South African Innocence Project: The study of DNA extracted from historical crime scene.
Nanotechnology is a new technology that can be applied to DNA genotyping.
Nanotechnology methods to isolate DNA.

Food Biotechnology

It is possible to conduct research in order to create innovative methods and processes in the fields of food processing and water. The most fascinating topics include:

A molecular-based technology that allows for the rapid identification and detection of foodborne pathogens in intricate food chains.
The effects of conventional and modern processing techniques on the bacteria that are associated with Aspalathus lineriasis.
DNA-based identification of species of animals that are present in meat products that are sold raw.
The phage assay and PCR are used to detect and limit the spread of foodborne pathogens.
Retention and elimination of pathogenic, heat-resistant and other microorganisms that are treated by UV-C.
Analysis of an F1 generation of the cross Bon Rouge x Packham's Triumph by Simple Sequence Repeat (SSR/microsatellite).
The identification of heavy metal tolerant and sensitive genotypes
Identification of genes that are involved in tolerance to heavy metals
The isolation of novel growth-promoting bacteria that can help crops cope with heavy metal stress . Identification of proteins that signal lipids to increase the tolerance of plants to stress from heavy metals

This topic includes high-resolution protein expression profiling for the investigation of proteome profiles. The following are a few of the most fascinating topics:

The identification and profile of stress-responsive proteins that respond to abiotic stress in Arabidopsis Thalian and Sorghum bicolor.
Analyzing sugar biosynthesis-related proteins in Sorghum bicolor, and study of their roles in drought stress tolerance
Evaluation of the viability and long-term sustainability of Sweet Sorghum for bioethanol (and other by-products) production in South Africa
In the direction of developing an environmentally sustainable, low-tech hypoallergenic latex Agroprocessing System designed specifically especially for South African small-holder farmers.

Bioinformatics

This is an additional aspect of biotechnology research. The current trend is to discover new methods to combat cancer. Bioinformatics may help identify proteins and genes as well as their role in the fight against cancer. Check out some of the areas that are suitable to study.

Prediction of anticancer peptides with HIMMER and the the support vector machine.
The identification and verification of innovative therapeutic antimicrobial peptides for Human Immunodeficiency Virus In the lab and molecular method.
The identification of biomarkers that are associated with cancer of the ovary using an molecular and in-silico method.
Biomarkers identified in breast cancer, as possible therapeutic and diagnostic agents with a combination of molecular and in-silico approaches.
The identification of MiRNA's as biomarkers for screening of cancerous prostates in the early stages an in-silico and molecular method
Identification of putatively identified the genes present in breast cancer tissues as biomarkers for early detection of lobular and ductal breast cancers.
Examining the significance of Retinoblastoma Binding Protein 6 (RBBP6) in the regulation of the cancer-related protein Y-Box Binding Protein 1 (YB-1).
Examining the role played by Retinoblastoma Binding Protein 6 (RBBP6) in the regulation of the cancer suppressor p53 through Mouse Double Minute 2 (MDM2).
Structural analysis of the anti-oxidant properties of the 1-Cys peroxiredoxin Prx2 found in the plant that resurrects itself Xerophyta viscosa.

Nanotechnology

This is a fascinating aspect of biotechnology, which can be used to identify effective tools to address the most serious health issues.

Evaluation of cancer-specific peptides to determine their applications for the detection of cancer.
The development of a quantum dot-based detection systems for breast cancer.
The creation of targeted Nano-constructs for in vivo imaging as well as the treatment of tumors.
Novel quinone compounds are being tested as anti-cancer medicines.
Embedelin is delivered to malignant cells in a specific manner.
The anti-cancer activities of Tulbaghia Violacea extracts were studied biochemically .
Novel organic compounds are screened for their anti-cancer potential.
To treat HIV, nanotechnology-based therapeutic techniques are being developed.

Frequently asked questions

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Some of biotechnology topics are:

What are the research areas in biotechnology ?

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Molecular Biosciences Theses and Dissertations

Theses/dissertations from 2024 2024.

Androgen Drives Melanoma Invasiveness and Metastatic Spread by Inducing Tumorigenic Fucosylation , Qian Liu

Theses/Dissertations from 2023 2023

Exploring strain variation and bacteriophage predation in the gut microbiome of Ciona robusta , Celine Grace F. Atkinson

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression , Janine M. DeBlasi

Thermodynamic frustration of TAD2 and PRR contribute to autoinhibition of p53 , Emily Gregory

Utilization of Detonation Nanodiamonds: Nanocarrier for Gene Therapy in Non-Small Cell Lung Cancer , Allan E. Gutierrez

Utilizing neoantigen-specific CD4* T cells and immune checkpoint modulation to advance adoptive cell therapy with tumor-infiltrating lymphocytes for metastatic melanoma patients , Maclean Scott Hall

Role of HLA-DRB1 Fucosylation in Anti-Melanoma Immunity , Daniel K. Lester

Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML , Christopher T. Letson

The Role of the DNA Helicase Rrm3 under Replication Stress , Julius Muellner

Regulated Intramembrane Proteolysis by M82 Peptidases: The Role of PrsS in the Staphylococcus aureus Stress Response , Baylie M. Schott

Histone Deacetylase 8 is a Novel Therapeutic Target for Mantle Cell Lymphoma and Preserves Natural Killer Cell Cytotoxic Function , January M. Watters

Theses/Dissertations from 2022 2022

Ceramide-1-Phosphate: A Novel Regulator of Golgi Fragmentation, Golgi-ER Vesicle Trafficking, and Anaplasma phagocytophilum Pathogenesis , Anika Nayar Ali

Regulation of the Heat Shock Response via Lysine Acetyltransferase CBP-1 and in Neurodegenerative Disease in Caenorhabditis elegans , Lindsey N. Barrett

Establishment of a Melanoma ESC-GEMM Platform and Its Use to Study PTEN Tumor Suppressor Functions , Ilah Bok

Adrenergic Modulation of Precursor Cells of Ovarian Cancer , Sweta Dash

Determining the Role of Dendritic Cells During Response to Treatment with Paclitaxel/Anti-TIM-3 , Alycia Gardner

To be or not to be: A Tale of Staphylococcal GpsB , Lauren R. Hammond

Origin and Epigenetic Regulation of Cutaneous T Cell Lymphoma , Carly M. Harro

Cell-free DNA Methylation Signatures in Cancer Detection and Classification , Jinyong Huang

The Role Of Eicosanoid Metabolism in Mammalian Wound Healing and Inflammation , Kenneth D. Maus

A Holistic Investigation of Acidosis in Breast Cancer , Bryce Ordway

Characterizing the Impact of Postharvest Temperature Stress on Polyphenol Profiles of Red and White-Fruited Strawberry Cultivars , Alyssa N. Smith

Identification of Secondary Structural Elements Contained Within the Intrinsically Disordered N-Terminal Tail of the Bloom’s Syndrome Helicase. , Vivek Somasundaram

Defining the role of Oxidized Mitochondrial DNA in Myelodysplastic Syndromes , Grace Anne Ward

Lord of the Z-rings: Uncovering the Role of MraZ and FtsL in Bacillus subtilis Cell Division , Maria Louise White

Theses/Dissertations from 2021 2021

Multifaceted Approach to Understanding Acinetobacter baumannii Biofilm Formation and Drug Resistance , Jessie L. Allen

Cellular And Molecular Alterations Associated with Ovarian and Renal Cancer Pathophysiology , Ravneet Kaur Chhabra

Ecology and diversity of boletes of the southeastern United States , Arian Farid

CircREV1 Expression in Triple-Negative Breast Cancer , Meagan P. Horton

Microbial Dark Matter: Culturing the Uncultured in Search of Novel Chemotaxonomy , Sarah J. Kennedy

The Multifaceted Role of CCAR-1 in the Alternative Splicing and Germline Regulation in Caenorhabditis elegans , Doreen Ikhuva Lugano

Unraveling the Role of Novel G5 Peptidase Family Proteins in Virulence and Cell Envelope Biogenesis of Staphylococcus aureus , Stephanie M. Marroquin

Cytoplasmic Polyadenylation Element Binding Protein 2 Alternative Splicing Regulates HIF1α During Chronic Hypoxia , Emily M. Mayo

Transcriptomic and Functional Investigation of Bacterial Biofilm Formation , Brooke R. Nemec

A Functional Characterization of the Omega (ω) subunit of RNA Polymerase in Staphylococcus aureus , Shrushti B. Patil

The Role Of Cpeb2 Alternative Splicing In TNBC Metastasis , Shaun C. Stevens

Screening Next-generation Fluorine-19 Probe and Preparation of Yeast-derived G Proteins for GPCR Conformation and Dynamics Study , Wenjie Zhao

Theses/Dissertations from 2020 2020

Understanding the Role of Cereblon in Hematopoiesis Through Structural and Functional Analyses , Afua Adutwumwa Akuffo

To Mid-cell and Beyond: Characterizing the Roles of GpsB and YpsA in Cell Division Regulation in Gram-positive Bacteria , Robert S. Brzozowski

Spatiotemporal Changes of Microbial Community Assemblages and Functions in the Subsurface , Madison C. Davis

New Mechanisms That Regulate DNA Double-Strand Break-Induced Gene Silencing and Genome Integrity , Dante Francis DeAscanis

Regulation of the Heat Shock Response and HSF-1 Nuclear Stress Bodies in C. elegans , Andrew Deonarine

New Mechanisms that Control FACT Histone Chaperone and Transcription-mediated Genome Stability , Angelo Vincenzo de Vivo Diaz

Targeting the ESKAPE Pathogens by Botanical and Microbial Approaches , Emily Dilandro

Succession in native groundwater microbial communities in response to effluent wastewater , Chelsea M. Dinon

Role of ceramide-1 phosphate in regulation of sphingolipid and eicosanoid metabolism in lung epithelial cells , Brittany A. Dudley

Allosteric Control of Proteins: New Methods and Mechanisms , Nalvi Duro

Microbial Community Structures in Three Bahamian Blue Holes , Meghan J. Gordon

A Novel Intramolecular Interaction in P53 , Fan He

The Impact of Myeloid-Mediated Co-Stimulation and Immunosuppression on the Anti-Tumor Efficacy of Adoptive T cell Therapy , Pasquale Patrick Innamarato

Investigating Mechanisms of Immune Suppression Secondary to an Inflammatory Microenvironment , Wendy Michelle Kandell

Posttranslational Modification and Protein Disorder Regulate Protein-Protein Interactions and DNA Binding Specificity of p53 , Robin Levy

Mechanistic and Translational Studies on Skeletal Malignancies , Jeremy McGuire

Novel Long Non-Coding RNA CDLINC Promotes NSCLC Progression , Christina J. Moss

Genome Maintenance Roles of Polycomb Transcriptional Repressors BMI1 and RNF2 , Anthony Richard Sanchez IV

The Ecology and Conservation of an Urban Karst Subterranean Estuary , Robert J. Scharping

Biological and Proteomic Characterization of Cornus officinalis on Human 1.1B4 Pancreatic β Cells: Exploring Use for T1D Interventional Application , Arielle E. Tawfik

Evaluation of Aging and Genetic Mutation Variants on Tauopathy , Amber M. Tetlow

Theses/Dissertations from 2019 2019

Investigating the Proteinaceous Regulome of the Acinetobacter baumannii , Leila G. Casella

Functional Characterization of the Ovarian Tumor Domain Deubiquitinating Enzyme 6B , Jasmin M. D'Andrea

Integrated Molecular Characterization of Lung Adenocarcinoma with Implications for Immunotherapy , Nicholas T. Gimbrone

The Role of Secreted Proteases in Regulating Disease Progression in Staphylococcus aureus , Brittney D. Gimza

Advanced Proteomic and Epigenetic Characterization of Ethanol-Induced Microglial Activation , Jennifer Guergues Guergues

Understanding immunometabolic and suppressive factors that impact cancer development , Rebecca Swearingen Hesterberg

Biochemical and Proteomic Approaches to Determine the Impact Level of Each Step of the Supply Chain on Tomato Fruit Quality , Robert T. Madden

Enhancing Immunotherapeutic Interventions for Treatment of Chronic Lymphocytic Leukemia , Kamira K. Maharaj

Characterization of the Autophagic-Iron Axis in the Pathophysiology of Endometriosis and Epithelial Ovarian Cancers , Stephanie Rockfield

Understanding the Influence of the Cancer Microenvironment on Metabolism and Metastasis , Shonagh Russell

Modeling of Interaction of Ions with Ether- and Ester-linked Phospholipids , Matthew W. Saunders

Novel Insights into the Multifaceted Roles of BLM in the Maintenance of Genome Stability , Vivek M. Shastri

Conserved glycine residues control transient helicity and disorder in the cold regulated protein, Cor15a , Oluwakemi Sowemimo

A Novel Cytokine Response Modulatory Function of MEK Inhibitors Mediates Therapeutic Efficacy , Mengyu Xie

Novel Strategies on Characterizing Biologically Specific Protein-protein Interaction Networks , Bi Zhao

Theses/Dissertations from 2018 2018

Characterization of the Transcriptional Elongation Factor ELL3 in B cells and Its Role in B-cell Lymphoma Proliferation and Survival , Lou-Ella M.m. Alexander

Identification of Regulatory miRNAs Associated with Ethanol-Induced Microglial Activation Using Integrated Proteomic and Transcriptomic Approaches , Brandi Jo Cook

Molecular Phylogenetics of Floridian Boletes , Arian Farid

MYC Distant Enhancers Underlie Ovarian Cancer Susceptibility at the 8q24.21 Locus , Anxhela Gjyshi Gustafson

Quantitative Proteomics to Support Translational Cancer Research , Melissa Hoffman

A Systems Chemical Biology Approach for Dissecting Differential Molecular Mechanisms of Action of Clinical Kinase Inhibitors in Lung Cancer , Natalia Junqueira Sumi

Investigating the Roles of Fucosylation and Calcium Signaling in Melanoma Invasion , Tyler S. Keeley

Synthesis, Oxidation, and Distribution of Polyphenols in Strawberry Fruit During Cold Storage , Katrina E. Kelly

Investigation of Alcohol-Induced Changes in Hepatic Histone Modifications Using Mass Spectrometry Based Proteomics , Crystina Leah Kriss

Off-Target Based Drug Repurposing Using Systems Pharmacology , Brent M. Kuenzi

Investigation of Anemarrhena asphodeloides and its Constituent Timosaponin-AIII as Novel, Naturally Derived Adjunctive Therapeutics for the Treatment of Advanced Pancreatic Cancer , Catherine B. MarElia

The Role of Phosphohistidine Phosphatase 1 in Ethanol-induced Liver Injury , Daniel Richard Martin

Theses/Dissertations from 2017 2017

Changing the Pathobiological Paradigm in Myelodysplastic Syndromes: The NLRP3 Inflammasome Drives the MDS Phenotype , Ashley Basiorka

Modeling of Dynamic Allostery in Proteins Enabled by Machine Learning , Mohsen Botlani-Esfahani

Uncovering Transcriptional Activators and Targets of HSF-1 in Caenorhabditis elegans , Jessica Brunquell

The Role of Sgs1 and Exo1 in the Maintenance of Genome Stability. , Lillian Campos-Doerfler

Mechanisms of IKBKE Activation in Cancer , Sridevi Challa

Discovering Antibacterial and Anti-Resistance Agents Targeting Multi-Drug Resistant ESKAPE Pathogens , Renee Fleeman

Functional Roles of Matrix Metalloproteinases in Bone Metastatic Prostate Cancer , Jeremy S. Frieling

Disorder Levels of c-Myb Transactivation Domain Regulate its Binding Affinity to the KIX Domain of CREB Binding Protein , Anusha Poosapati

Role of Heat Shock Transcription Factor 1 in Ovarian Cancer Epithelial-Mesenchymal Transition and Drug Sensitivity , Chase David Powell

Cell Division Regulation in Staphylococcus aureus , Catherine M. Spanoudis

A Novel Approach to the Discovery of Natural Products From Actinobacteria , Rahmy Tawfik

Non-classical regulators in Staphylococcus aureus , Andy Weiss

Theses/Dissertations from 2016 2016

In Vitro and In Vivo Antioxidant Capacity of Synthetic and Natural Polyphenolic Compounds Identified from Strawberry and Fruit Juices , Marvin Abountiolas

Quantitative Proteomic Investigation of Disease Models of Type 2 Diabetes , Mark Gabriel Athanason

CMG Helicase Assembly and Activation: Regulation by c-Myc through Chromatin Decondensation and Novel Therapeutic Avenues for Cancer Treatment , Victoria Bryant

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Biotechnology Research Paper Topics

This collection of biotechnology research paper topics provides the list of 10 potential topics for research papers and overviews the history of biotechnology.

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Get 10% off with 24start discount code, 1. animal breeding: genetic methods.

Modern animal breeding relies on scientific methods to control production of domesticated animals, both livestock and pets, which exhibit desired physical and behavioral traits. Genetic technology aids animal breeders to attain nutritional, medical, recreational, and fashion standards demanded by consumers for animal products including meat, milk, eggs, leather, wool, and pharmaceuticals. Animals are also genetically designed to meet labor and sporting requirements for speed and endurance, conformation and beauty ideals to win show competitions, and intelligence levels to perform obediently at tasks such as herding, hunting, and tracking. By the late twentieth century, genetics and mathematical models were appropriated to identify the potential of immature animals. DNA markers indicate how young animals will mature, saving breeders money by not investing in animals lacking genetic promise. Scientists also successfully transplanted sperm-producing stem cells with the goal of restoring fertility to barren breeding animals. At the National Animal Disease Center in Ames, Iowa, researchers created a gene-based test, which uses a cloned gene of the organism that causes Johne’s disease in cattle in order to detect that disease to avert epidemics. Researchers also began mapping the dog genome and developing molecular techniques to evaluate canine chromosomes in the Quantitative Trait Loci (QTL). Bioinformatics incorporates computers to analyze genetic material. Some tests were developed to diagnose many of several hundred genetic canine diseases including hip dysplasia and progressive retinal atrophy (PRA). A few breed organizations modified standards to discourage breeding of genetically flawed animals and promote heterozygosity.

2. Antibacterial Chemotherapy

In the early years of the twentieth century, the search for agents that would be effective against internal infections proceeded along two main routes. The first was a search for naturally occurring substances that were effective against microorganisms (antibiosis). The second was a search for chemicals that would have the same effect (chemotherapy). Despite the success of penicillin in the 1940s, the major early advances in the treatment of infection occurred not through antibiosis but through chemotherapy. The principle behind chemotherapy was that there was a relationship between chemical structure and pharmacological action. The founder of this concept was Paul Erhlich (1854–1915). An early success came in 1905 when atoxyl (an organic arsenic compound) was shown to destroy trypanosomes, the microbes that caused sleeping sickness. Unfortunately, atoxyl also damaged the optic nerve. Subsequently, Erhlich and his co-workers synthesized and tested hundreds of related arsenic compounds. Ehrlich was a co-recipient (with Ilya Ilyich Mechnikov) of the Nobel Prize in medicine in 1908 for his work on immunity. Success in discovering a range of effective antibacterial drugs had three important consequences: it brought a range of important diseases under control for the first time; it provided a tremendous stimulus to research workers and opened up new avenues of research; and in the resulting commercial optimism, it led to heavy postwar investment in the pharmaceutical industry. The therapeutic revolution had begun.

3. Artificial Insemination and in Vitro Fertilization

Artificial insemination (AI) involves the extraction and collection of semen together with techniques for depositing semen in the uterus in order to achieve successful fertilization and pregnancy. Throughout the twentieth century, the approach has offered animal breeders the advantage of being able to utilize the best available breeding stock and at the correct time within the female reproductive cycle, but without the limitations of having the animals in the same location. AI has been applied most intensively within the dairy and beef cattle industries and to a lesser extent horse breeding and numerous other domesticated species.

Many of the techniques involved in artificial insemination would lay the foundation for in vitro fertilization (IVF) in the latter half of the twentieth century. IVF refers to the group of technologies that allow fertilization to take place outside the body involving the retrieval of ova or eggs from the female and sperm from the male, which are then combined in artificial, or ‘‘test tube,’’ conditions leading to fertilization. The fertilized eggs then continue to develop for several days ‘‘in culture’’ until being transferred to the female recipient to continue developing within the uterus.

4. Biopolymers

Biopolymers are natural polymers, long-chained molecules (macromolecules) consisting mostly of a repeated composition of building blocks or monomers that are formed and utilized by living organisms. Each group of biopolymers is composed of different building blocks, for example chains of sugar molecules form starch (a polysaccharide), chains of amino acids form proteins and peptides, and chains of nucleic acid form DNA and RNA (polynucleotides). Biopolymers can form gels, fibers, coatings, and films depending on the specific polymer, and serve a variety of critical functions for cells and organisms. Proteins including collagens, keratins, silks, tubulins, and actin usually form structural composites or scaffolding, or protective materials in biological systems (e.g., spider silk). Polysaccharides function in molecular recognition at cell membrane surfaces, form capsular barrier layers around cells, act as emulsifiers and adhesives, and serve as skeletal or architectural materials in plants. In many cases these polymers occur in combination with proteins to form novel composite structures such as invertebrate exoskeletons or microbial cell walls, or with lignin in the case of plant cell walls.

The use of the word ‘‘cloning’’ is fraught with confusion and inconsistency, and it is important at the outset of this discussion to offer definitional clarification. For instance, in the 1997 article by Ian Wilmut and colleagues announcing the birth of the first cloned adult vertebrate (a ewe, Dolly the sheep) from somatic cell nuclear transfer, the word clone or cloning was never used, and yet the announcement raised considerable disquiet about the prospect of cloned human beings. In a desire to avoid potentially negative forms of language, many prefer to substitute ‘‘cell expansion techniques’’ or ‘‘therapeutic cloning’’ for cloning. Cloning has been known for centuries as a horticultural propagation method: for example, plants multiplied by grafting, budding, or cuttings do not differ genetically from the original plant. The term clone entered more common usage as a result of a speech in 1963 by J.B.S. Haldane based on his paper, ‘‘Biological possibilities for the human species of the next ten-thousand years.’’ Notwithstanding these notes of caution, we can refer to a number of processes as cloning. At the close of the twentieth century, such techniques had not yet progressed to the ability to bring a cloned human to full development; however, the ability to clone cells from an adult human has potential to treat diseases. International policymaking in the late 1990s sought to distinguish between the different end uses for somatic cell nuclear transfer resulting in the widespread adoption of the distinction between ‘‘reproductive’’ and ‘‘therapeutic’’ cloning. The function of the distinction has been to permit the use (in some countries) of the technique to generate potentially beneficial therapeutic applications from embryonic stem cell technology whilst prohibiting its use in human reproduction. In therapeutic applications, nuclear transfer from a patient’s cells into an enucleated ovum is used to create genetically identical embryos that would be grown in vitro but not be allowed to continue developing to become a human being. The resulting cloned embryos could be used as a source from which to produce stem cells that can then be induced to specialize into the specific type of tissue required by the patient (such as skin for burns victims, brain neuron cells for Parkinson’s disease sufferers, or pancreatic cells for diabetics). The rationale is that because the original nuclear material is derived from a patient’s adult tissue, the risks of rejection of such cells by the immune system are reduced.

6. Gene Therapy

In 1971, Australian Nobel laureate Sir F. MacFarlane Burnet thought that gene therapy (introducing genes into body tissue, usually to treat an inherited genetic disorder) looked more and more like a case of the emperor’s new clothes. Ethical issues aside, he believed that practical considerations forestalled possibilities for any beneficial gene strategy, then or probably ever. Bluntly, he wrote: ‘‘little further advance can be expected from laboratory science in the handling of ‘intrinsic’ types of disability and disease.’’ Joshua Lederberg and Edward Tatum, 1958 Nobel laureates, theorized in the 1960s that genes might be altered or replaced using viral vectors to treat human diseases. Stanfield Rogers, working from the Oak Ridge National Laboratory in 1970, had tried but failed to cure argininemia (a genetic disorder of the urea cycle that causes neurological damage in the form of mental retardation, seizures, and eventually death) in two German girls using Swope papilloma virus. Martin Cline at the University of California in Los Angeles, made the second failed attempt a decade later. He tried to correct the bone marrow cells of two beta-thalassemia patients, one in Israel and the other in Italy. What Cline’s failure revealed, however, was that many researchers who condemned his trial as unethical were by then working toward similar goals and targeting different diseases with various delivery methods. While Burnet’s pessimism finally proved to be wrong, progress in gene therapy was much slower than antibiotic or anticancer chemotherapy developments over the same period of time. While gene therapy had limited success, it nevertheless remained an active area for research, particularly because the Human Genome Project, begun in 1990, had resulted in a ‘‘rough draft’’ of all human genes by 2001, and was completed in 2003. Gene mapping created the means for analyzing the expression patterns of hundreds of genes involved in biological pathways and for identifying single nucleotide polymorphisms (SNPs) that have diagnostic and therapeutic potential for treating specific diseases in individuals. In the future, gene therapies may prove effective at protecting patients from adverse drug reactions or changing the biochemical nature of a person’s disease. They may also target blood vessel formation in order to prevent heart disease or blindness due to macular degeneration or diabetic retinopathy. One of the oldest ideas for use of gene therapy is to produce anticancer vaccines. One method involves inserting a granulocyte-macrophage colony-stimulating factor gene into prostate tumor cells removed in surgery. The cells then are irradiated to prevent any further cancer and injected back into the same patient to initiate an immune response against any remaining metastases. Whether or not such developments become a major treatment modality, no one now believes, as MacFarland Burnet did in 1970, that gene therapy science has reached an end in its potential to advance health.

7. Genetic Engineering

The term ‘‘genetic engineering’’ describes molecular biology techniques that allow geneticists to analyze and manipulate deoxyribonucleic acid (DNA). At the close of the twentieth century, genetic engineering promised to revolutionize many industries, including microbial biotechnology, agriculture, and medicine. It also sparked controversy over potential health and ecological hazards due to the unprecedented ability to bypass traditional biological reproduction.

For centuries, if not millennia, techniques have been employed to alter the genetic characteristics of animals and plants to enhance specifically desired traits. In a great many cases, breeds with which we are most familiar bear little resemblance to the wild varieties from which they are derived. Canine breeds, for instance, have been selectively tailored to changing esthetic tastes over many years, altering their appearance, behavior and temperament. Many of the species used in farming reflect long-term alterations to enhance meat, milk, and fleece yields. Likewise, in the case of agricultural varieties, hybridization and selective breeding have resulted in crops that are adapted to specific production conditions and regional demands. Genetic engineering differs from these traditional methods of plant and animal breeding in some very important respects. First, genes from one organism can be extracted and recombined with those of another (using recombinant DNA, or rDNA, technology) without either organism having to be of the same species. Second, removing the requirement for species reproductive compatibility, new genetic combinations can be produced in a much more highly accelerated way than before. Since the development of the first rDNA organism by Stanley Cohen and Herbert Boyer in 1973, a number of techniques have been found to produce highly novel products derived from transgenic plants and animals.

At the same time, there has been an ongoing and ferocious political debate over the environmental and health risks to humans of genetically altered species. The rise of genetic engineering may be characterized by developments during the last three decades of the twentieth century.

8. Genetic Screening and Testing

The menu of genetic screening and testing technologies now available in most developed countries increased rapidly in the closing years of the twentieth century. These technologies emerged within the context of rapidly changing social and legal contexts with regard to the medicalization of pregnancy and birth and the legalization of abortion. The earliest genetic screening tests detected inborn errors of metabolism and sex-linked disorders. Technological innovations in genomic mapping and DNA sequencing, together with an explosion in research on the genetic basis of disease which culminated in the Human Genome Project (HGP), led to a range of genetic screening and testing for diseases traditionally recognized as genetic in origin and for susceptibility to more common diseases such as certain types of familial cancer, cardiac conditions, and neurological disorders among others. Tests were also useful for forensic, or nonmedical, purposes. Genetic screening techniques are now available in conjunction with in vitro fertilization and other types of reproductive technologies, allowing the screening of fertilized embryos for certain genetic mutations before selection for implantation. At present selection is purely on disease grounds and selection for other traits (e.g., for eye or hair color, intelligence, height) cannot yet be done, though there are concerns for eugenics and ‘‘designer babies.’’ Screening is available for an increasing number of metabolic diseases through tandem mass spectrometry, which uses less blood per test, allows testing for many conditions simultaneously, and has a very low false-positive rate as compared to conventional Guthrie testing. Finally, genetic technologies are being used in the judicial domain for determination of paternity, often associated with child support claims, and for forensic purposes in cases where DNA material is available for testing.

9. Plant Breeding: Genetic Methods

The cultivation of plants is the world’s oldest biotechnology. We have continually tried to produce improved varieties while increasing yield, features to aid cultivation and harvesting, disease, and pest resistance, or crop qualities such as longer postharvest storage life and improved taste or nutritional value. Early changes resulted from random crosspollination, rudimentary grafting, or spontaneous genetic change. For centuries, man kept the seed from the plants with improved characteristics to plant the following season’s crop. The pioneering work of Gregor Mendel and his development of the basic laws of heredity showed for other first time that some of the processes of heredity could be altered by experimental means. The genetic analysis of bacterial (prokaryote) genes and techniques for analysis of the higher (eukaryotic) organisms such as plants developed in parallel streams, but the rediscovery of Mendel’s work in 1900 fueled a burst of activity on understanding the role of genes in inheritance. The knowledge that genes are linked along the chromosome thereby allowed mapping of genes (transduction analysis, conjugation analysis, and transformation analysis). The power of genetics to produce a desirable plant was established, and it was appreciated that controlled breeding (test crosses and back crosses) and careful analysis of the progeny could distinguish traits that were dominant or recessive, and establish pure breeding lines. Traditional horticultural techniques of artificial self-pollination and cross-pollination were also used to produce hybrids. In the 1930s the Russian Nikolai Vavilov recognized the value of genetic diversity in domesticated crop plants and their wild relatives to crop improvement, and collected seeds from the wild to study total genetic diversity and use these in breeding programs. The impact of scientific crop breeding was established by the ‘‘Green revolution’’ of the 1960s, when new wheat varieties with higher yields were developed by careful crop breeding. ‘‘Mutation breeding’’— inducing mutations by exposing seeds to x-rays or chemicals such as sodium azide, accelerated after World War II. It was also discovered that plant cells and tissues grown in tissue culture would mutate rapidly. In the 1970s, haploid breeding, which involves producing plants from two identical sets of chromosomes, was extensively used to create new cultivars. In the twenty-first century, haploid breeding could speed up plant breeding by shortening the breeding cycle.

10. Tissue Culturing

The technique of tissue or cell culture, which relates to the growth of tissue or cells within a laboratory setting, underlies a phenomenal proportion of biomedical research. Though it has roots in the late nineteenth century, when numerous scientists tried to grow samples in alien environments, cell culture is credited as truly beginning with the first concrete evidence of successful growth in vitro, demonstrated by Johns Hopkins University embryologist Ross Harrison in 1907. Harrison took sections of spinal cord from a frog embryo, placed them on a glass cover slip and bathed the tissue in a nutrient media. The results of the experiment were startling—for the first time scientists visualized actual nerve growth as it would happen in a living organism—and many other scientists across the U.S. and Europe took up culture techniques. Rather unwittingly, for he was merely trying to settle a professional dispute regarding the origin of nerve fibers, Harrison fashioned a research tool that has since been designated by many as the greatest advance in medical science since the invention of the microscope.

From the 1980s, cell culture has once again been brought to the forefront of cancer research in the isolation and identification of numerous cancer causing oncogenes. In addition, cell culturing continues to play a crucial role in fields such as cytology, embryology, radiology, and molecular genetics. In the future, its relevance to direct clinical treatment might be further increased by the growth in culture of stem cells and tissue replacement therapies that can be tailored for a particular individual. Indeed, as cell culture approaches its centenary, it appears that its importance to scientific, medical, and commercial research the world over will only increase in the twenty-first century.

History of Biotechnology

Biotechnology grew out of the technology of fermentation, which was called zymotechnology. This was different from the ancient craft of brewing because of its thought-out relationships to science. These were most famously conceptualized by the Prussian chemist Georg Ernst Stahl (1659–1734) in his 1697 treatise Zymotechnia Fundamentalis, in which he introduced the term zymotechnology. Carl Balling, long-serving professor in Prague, the world center of brewing, drew on the work of Stahl when he published his Bericht uber die Fortschritte der zymotechnische Wissenschaften und Gewerbe (Account of the Progress of the Zymotechnic Sciences and Arts) in the mid-nineteenth century. He used the idea of zymotechnics to compete with his German contemporary Justus Liebig for whom chemistry was the underpinning of all processes.

By the end of the nineteenth century, there were attempts to develop a new scientific study of fermentation. It was an aspect of the ‘‘second’’ Industrial Revolution during the period from 1870 to 1914. The emergence of the chemical industry is widely taken as emblematic of the formal research and development taking place at the time. The development of microbiological industries is another example. For the first time, Louis Pasteur’s germ theory made it possible to provide convincing explanations of brewing and other fermentation processes.

Pasteur had published on brewing in the wake of France’s humiliation in the Franco–Prussian war (1870–1871) to assert his country’s superiority in an industry traditionally associated with Germany. Yet the science and technology of fermentation had a wide range of applications including the manufacture of foods (cheese, yogurt, wine, vinegar, and tea), of commodities (tobacco and leather), and of chemicals (lactic acid, citric acid, and the enzyme takaminase). The concept of zymotechnology associated principally with the brewing of beer began to appear too limited to its principal exponents. At the time, Denmark was the world leader in creating high-value agricultural produce. Cooperative farms pioneered intensive pig fattening as well as the mass production of bacon, butter, and beer. It was here that the systems of science and technology were integrated and reintegrated, conceptualized and reconceptualized.

The Dane Emil Christian Hansen discovered that infection from wild yeasts was responsible for numerous failed brews. His contemporary Alfred Jørgensen, a Copenhagen consultant closely associated with the Tuborg brewery, published a widely used textbook on zymotechnology. Microorganisms and Fermentation first appeared in Danish 1889 and would be translated, reedited, and reissued for the next 60 years.

The scarcity of resources on both sides during World War I brought together science and technology, further development of zymotechnology, and formulation of the concept of biotechnology. Impending and then actual war accelerated the use of fermentation technologies to make strategic materials. In Britain a variant of a process to ferment starch to make butadiene for synthetic rubber production was adapted to make acetone needed in the manufacture of explosives. The process was technically important as the first industrial sterile fermentation and was strategically important for munitions supplies. The developer, chemist Chaim Weizmann, later became well known as the first president of Israel in 1949.

In Germany scarce oil-based lubricants were replaced by glycerol made by fermentation. Animal feed was derived from yeast grown with the aid of the new synthetic ammonia in another wartime development that inspired the coining of the word biotechnology. Hungary was the agricultural base of the Austro–Hungarian empire and aspired to Danish levels of efficiency. The economist Karl Ereky (1878–1952) planned to go further and build the largest industrial pig-processing factory. He envisioned a site that would fatten 50,000 swine at a time while railroad cars of sugar beet arrived and fat, hides, and meat departed. In this forerunner of the Soviet collective farm, peasants (in any case now falling prey to the temptations of urban society) would be completely superseded by the industrialization of the biological process in large factory-like animal processing units. Ereky went further in his ruminations over the meaning of his innovation. He suggested that it presaged an industrial revolution that would follow the transformation of chemical technology. In his book entitled Biotechnologie, he linked specific technical injunctions to wide-ranging philosophy. Ereky was neither isolated nor obscure. He had been trained in the mainstream of reflection on the meaning of the applied sciences in Hungary, which would be remarkably productive across the sciences. After World War I, Ereky served as Hungary’s minister of food in the short-lived right wing regime that succeeded the fall of the communist government of Bela Kun.

Nonetheless it was not through Ereky’s direct action that his ideas seem to have spread. Rather, his book was reviewed by the influential Paul Lindner, head of botany at the Institut fu¨ r Ga¨ rungsgewerbe in Berlin, who suggested that microorganisms could also be seen as biotechnological machines. This concept was already found in the production of yeast and in Weizmann’s work with strategic materials, which was widely publicized at that very time. It was with this meaning that the word ‘‘Biotechnologie’’ entered German dictionaries in the 1920s.

Biotechnology represented more than the manipulation of existing organisms. From the beginning it was concerned with their improvement as well, and this meant the enhancement of all living creatures. Most dramatically this would include humanity itself; more mundanely it would include plants and animals of agricultural importance. The enhancement of people was called eugenics by the Victorian polymath and cousin of Charles Darwin, Francis Galton. Two strains of eugenics emerged: negative eugenics associated with weeding out the weak and positive eugenics associated with enhancing strength. In the early twentieth century, many eugenics proponents believed that the weak could be made strong. People had after all progressed beyond their biological limits by means of technology.

Jean-Jacques Virey, a follower of the French naturalist Jean-Baptiste de Monet de Lamarck, had coined the term ‘‘biotechnie’’ in 1828 to describe man’s ability to make technology do the work of biology, but it was not till a century later that the term entered widespread use. The Scottish biologist and town planner Patrick Geddes made biotechnics popular in the English-speaking world. Geddes, too, sought to link life and technology. Before World War I he had characterized the technological evolution of mankind as a move from the paleotechnic era of coal and iron to the neotechnic era of chemicals, electricity, and steel. After the war, he detected a new era based on biology—the biotechnic era. Through his friend, writer Lewis Mumford, Geddes would have great influence. Mumford’s book Technics and Civilization, itself a founding volume of the modern historiography of technology, promoted his vision of the Geddesian evolution.

A younger generation of English experimental biologists with a special interest in genetics, including J. B. S. Haldane, Julian Huxley, and Lancelot Hogben, also promoted a concept of biotechnology in the period between the world wars. Because they wrote popular works, they were among Britain’s best-known scientists. Haldane wrote about biological invention in his far-seeing work Daedalus. Huxley looked forward to a blend of social and eugenics-based biological engineering. Hogben, following Geddes, was more interested in engineering plants through breeding. He tied the progressivism of biology to the advance of socialism.

The improvement of the human race, genetic manipulation of bacteria, and the development of fermentation technology were brought together by the development of penicillin during World War II. This drug was successfully extracted from the juice exuded by a strain of the Penicillium fungus. Although discovered by accident and then developed further for purely scientific reasons, the scarce and unstable ‘‘antibiotic’’ called penicillin was transformed during World War II into a powerful and widely used drug. Large networks of academic and government laboratories and pharmaceutical manufacturers in Britain and the U.S. were coordinated by agencies of the two governments. An unanticipated combination of genetics, biochemistry, chemistry, and chemical engineering skills had been required. When the natural mold was bombarded with high-frequency radiation, far more productive mutants were produced, and subsequently all the medicine was made using the product of these man-made cells. By the 1950s penicillin was cheap to produce and globally available.

The new technology of cultivating and processing large quantities of microorganisms led to calls for a new scientific discipline. Biochemical engineering was one term, and applied microbiology another. The Swedish biologist, Carl-Goran Heden, possibly influenced by German precedents, favored the term ‘‘Biotechnologi’’ and persuaded his friend Elmer Gaden to relabel his new journal Biotechnology and Biochemical Engineering. From 1962 major international conferences were held under the banner of the Global Impact of Applied Microbiology. During the 1960s food based on single-cell protein grown in fermenters on oil or glucose seemed, to visionary engineers and microbiologists and to major companies, to offer an immediate solution to world hunger. Tropical countries rich in biomass that could be used as raw material for fermentation were also the world’s poorest. Alcohol could be manufactured by fermenting such starch or sugar rich crops as sugar cane and corn. Brazil introduced a national program of replacing oil-based petrol with alcohol in the 1970s.

It was not, however, just the developing countries that hoped to benefit. The Soviet Union developed fermentation-based protein as a major source of animal feed through the 1980s. In the U.S. it seemed that oil from surplus corn would solve the problem of low farm prices aggravated by the country’s boycott of the USSR in1979, and the term ‘‘gasohol‘‘ came into currency. Above all, the decline of established industries made the discovery of a new wealth maker an urgent priority for Western governments. Policy makers in both Germany and Japan during the 1970s were driven by a sense of the inadequacy of the last generation of technologies. These were apparently maturing, and the succession was far from clear. Even if electronics or space travel offered routes to the bright industrial future, these fields seemed to be dominated by the U.S. Seeing incipient crisis, the Green, or environmental, movement promoted a technology that would depend on renewable resources and on low-energy processes that would produce biodegradable products, recycle waste, and address problems of the health and nutrition of the world.

In 1973 the German government, seeking a new and ‘‘greener’’ industrial policy, commissioned a report entitled Biotechnologie that identified ways in which biological processing was key to modern developments in technology. Even though the report was published at the time that recombinant DNA (deoxyribonucleic acid) was becoming possible, it did not refer to this new technique and instead focused on the use and combination of existing technologies to make novel products.

Nonetheless the hitherto esoteric science of molecular biology was making considerable progress, although its practice in the early 1970s was rather distant from the world of industrial production. The phrase ‘‘genetic engineering’’ entered common parlance in the 1960s to describe human genetic modification. Medicine, however, put a premium on the use of proteins that were difficult to extract from people: insulin for diabetics and interferon for cancer sufferers. During the early 1970s what had been science fiction became fact as the use of DNA synthesis, restriction enzymes, and plasmids were integrated. In 1973 Stanley Cohen and Herbert Boyer successfully transferred a section of DNA from one E. coli bacterium to another. A few prophets such as Joshua Lederberg and Walter Gilbert argued that the new biological techniques of recombinant DNA might be ideal for making synthetic versions of expensive proteins such as insulin and interferon through their expression in bacterial cells. Small companies, such as Cetus and Genentech in California and Biogen in Cambridge, Massachusetts, were established to develop the techniques. In many cases discoveries made by small ‘‘boutique’’ companies were developed for the market by large, more established, pharmaceutical organizations.

Many governments were impressed by these advances in molecular genetics, which seemed to make biotechnology a potential counterpart to information technology in a third industrial revolution. These inspired hopes of industrial production of proteins identical to those produced in the human body that could be used to treat genetic diseases. There was also hope that industrially useful materials such as alcohol, plastics (biopolymers), or ready-colored fibers might be made in plants, and thus the attractions of a potentially new agricultural era might be as great as the implications for medicine. At a time of concern over low agricultural prices, such hopes were doubly welcome. Indeed, the agricultural benefits sometimes overshadowed the medical implications.

The mechanism for the transfer of enthusiasm from engineering fermenters to engineering genes was the New York Stock Exchange. At the end of the 1970s, new tax laws encouraged already adventurous U.S. investors to put money into small companies whose stock value might grow faster than their profits. The brokerage firm E. F. Hutton saw the potential for the new molecular biology companies such as Biogen and Cetus. Stock market interest in companies promising to make new biological entities was spurred by the 1980 decision of the U.S. Supreme Court to permit the patenting of a new organism. The patent was awarded to the Exxon researcher Ananda Chakrabarty for an organism that metabolized hydrocarbon waste. This event signaled the commercial potential of biotechnology to business and governments around the world. By the early 1980s there were widespread hopes that the protein interferon, made with some novel organism, would provide a cure for cancer. The development of monoclonal antibody technology that grew out of the work of Georges J. F. Kohler and Cesar Milstein in Cambridge (co-recipients with Niels K. Jerne of the Nobel Prize in medicine in 1986) seemed to offer new prospects for precise attacks on particular cells.

The fear of excessive regulatory controls encouraged business and scientific leaders to express optimistic projections about the potential of biotechnology. The early days of biotechnology were fired by hopes of medical products and high-value pharmaceuticals. Human insulin and interferon were early products, and a second generation included the anti-blood clotting agent tPA and the antianemia drug erythropoietin. Biotechnology was also used to help identify potential new drugs that might be made chemically, or synthetically.

At the same time agricultural products were also being developed. Three early products that each raised substantial problems were bacteria which inhibited the formation of frost on the leaves of strawberry plants (ice-minus bacteria), genetically modified plants including tomatoes and rapeseed, and the hormone bovine somatrotropin (BST) produced in genetically modified bacteria and administered to cattle in the U.S. to increase milk yields. By 1999 half the soy beans and one third of the corn grown in the U.S. were modified. Although the global spread of such products would arouse the best known concern at the end of the century, the use of the ice-minus bacteria— the first authorized release of a genetically engineered organism into the environment—had previously raised anxiety in the U.S. in the 1980s.

In 1997 Dolly the sheep was cloned from an adult mother in the Roslin agricultural research institute outside Edinburgh, Scotland. This work was inspired by the need to find a way of reproducing sheep engineered to express human proteins in their milk. However, the public interest was not so much in the cloning of sheep that had just been achieved as in the cloning of people, which had not. As in the Middle Ages when deformed creatures had been seen as monsters and portents of natural disasters, Dolly was similarly seen as monster and as a portent of human cloning.

The name Frankenstein, recalled from the story written by Mary Shelley at the beginning of the nineteenth century and from the movies of the 1930s, was once again familiar at the end of the twentieth century. Shelley had written in the shadow of Stahl’s theories. The continued appeal of this book embodies the continuity of the fears of artificial life and the anxiety over hubris. To this has been linked a more mundane suspicion of the blending of commerce and the exploitation of life. Discussion of biotechnology at the end of the twentieth century was therefore colored by questions of whose assurances of good intent and reassurance of safety could be trusted.

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FOCUSED RESEARCH TOPICS

Twin and family studies

Measured genetic variants

Quasi-experimental designs

Genetic influences on behaviour

Nature of environmental influence

Nature of genetic influence

Psychiatric genetics

Karyotyping

Banding technique

Comparative genome hybridization

FISH (fluorescent in situ hybridization)

Molecular basis

DNA damage

Techniques used to study epigenetics

ChIP-on-chip and ChIP-Seq)

Fluorescent in situ hybridization

Methylation-sensitive restriction enzymes

DNA adenine methyltransferase identification (DamID)

Bisulfite sequencing

Mechanisms

Covalent modifications

RNA transcripts

MicroRNAs

mRNA

sRNAs

Prions

Structural inheritance

Nucleosome positioning

Functions and consequences

Development

Transgenerational

Epigenetics and epigenetic drugs

Neurodegenerative diseases of motor neurons

Amyotrophic lateral sclerosis (ALS)

Spinal Muscular Atrophy (SMA)

Neurodegenerative Diseases of the Central Nervous System

Alzheimer's Disease (AD)

Huntington's Disease (HD)

Parkinson's Disease (PD)

Molecular basis for inheritance

DNA and chromosomes

Reproduction

Recombination and genetic linkage

Gene expression

Genetic code

Gene regulation

Genetic change

Mutations

Natural selection and evolution

Medicine

Research methods

DNA sequencing and genomics

Genetic testing:

Cell-free fetal DNA

Newborn screening

Diagnostic testing

Carrier testing:

Preimplantation genetic diagnosis

Prenatal diagnosis

Predictive and presymptomatic testing

Pharmacogenomics

Non-diagnostic testing:

Forensic testing

Paternity testing

Genealogical DNA test

Research testing

Genome analysis

Sequencing

Shotgun sequencing

High-throughput sequencing

Assembly

Assembly approaches

Finishing

Annotation

Sequencing pipelines and databases

Functional genomics

Structural genomics

Epigenomics

Metagenomics

Pharmacogenomics

Drug-metabolizing enzymes

Predictive prescribing

Polypharmacy

Drug labeling

Mitochondrial genes

Replication, repair, transcription and translation

Mitochondrial disease

Types of genetic disorder:

Single-gene

Autosomal dominant

Autosomal recessive

X-linked dominant

X-linked recessive

Y-linked

Mitochondrial

Causes of genetic disorder

Diagnosis

Treatment / gene therapy

List of genetic disorder:

1p36 deletion syndrome

18p deletion syndrome

21-hydroxylase deficiency

Alpha 1-antitrypsin deficiency

AAA syndrome (achalasia-addisonianism-alacrima)

Aarskog– Scott syndrome

ABCD syndrome

Aceruloplasminemia

Acheiropodia

Achondrogenesis type II

Achondroplasia

Acute intermittent porphyria

Adenylosuccinate lyase deficiency

Adrenoleukodystrophy

Alagille syndrome

Adult syndrome

Albinism

Alexander disease

Alkaptonuria

Alport syndrome

Alternating hemiplegia of childhood

Amyotrophic lateral sclerosis

Alström syndrome

Alzheimer's disease

Amelogenesis imperfecta

Aminolevulinic acid dehydratase deficiency porphyria

Androgen insensitivity syndrome

Angelman syndrome

Apert Syndrome

Arthrogryposis–renal dysfunction–cholestasis syndrome

Ataxia telangiectasia

Axenfeld syndrome

Beare-Stevenson cutis gyrata syndrome

Beckwith–Wiedemann syndrome

Benjamin syndrome

Biotinidase deficiency

Björnstad syndrome

Bloom syndrome

Birt–Hogg–Dubé syndrome

Brody myopathy

Cadasil syndrome

Carasil syndrome

Chronic granulomatous disorder

Campomelic dysplasia

Canavan disease

Carpenter Syndrome

Cerebral dysgenesis–neuropathy–ichthyosis–keratoderma syndrome (SEDNIK)

Cystic fibrosis

Charcot–Marie–Tooth disease

CHARGE syndrome

Chédiak–Higashi syndrome

Cleidocranial dysostosis

Cockayne syndrome

Coffin–Lowry syndrome

Cohen syndrome

Collagenopathy, types II and XI

Congenital insensitivity to pain with anhidrosis (CIPA)

Cowden syndrome

CPO deficiency (coproporphyria)

Cranio–lenticulo–sutural dysplasia

Cri du chat

Crohn's disease

Crouzon syndrome

Crouzonodermoskeletal syndrome (Crouzon syndrome with acanthosis nigricans)

Darier's disease

Dent's disease (Genetic hypercalciuria)

Denys–Drash syndrome

De Grouchy syndrome

Di George's syndrome

Distal hereditary motor neuropathies, multiple types

Ehlers–Danlos syndrome

Emery–Dreifuss syndrome

Erythropoietic protoporphyria

Fanconi anemia (FA)

Fabry disease

Factor V Leiden thrombophilia

Familial adenomatous polyposis

Familial dysautonomia

Feingold syndrome

FG syndrome

Friedreich's ataxia

G6PD deficiency

Galactosemia

Gaucher disease

Gillespie syndrome

Griscelli syndrome

Hailey-Hailey disease

Harlequin type ichthyosis

Hemochromatosis, hereditary

Hemophilia

Hepatoerythropoietic porphyria UROD

Hereditary coproporphyria

Hereditary hemorrhagic telangiectasia (Osler–Weber–Rendu syndrome)

Hereditary Inclusion Body Myopathy

Hereditary multiple exostoses

Hereditary spastic paraplegia (infantile-onset ascending hereditary spastic paralysis)

Hermansky–Pudlak syndrome

Hereditary neuropathy with liability to pressure palsies (HNPP)

Homocystinuria

Huntington's disease

Hunter syndrome

Hurler syndrome

Hutchinson-Gilford progeria syndrome

Hyperoxaluria, primary

Hyperphenylalaninemia

Hypoalphalipoproteinemia (Tangier disease)

Hypochondrogenesis

Hypochondroplasia

Immunodeficiency, centromere instability and facial anomalies syndrome (ICF syndrome)

Incontinentia pigmenti

Isodicentric 15

Jackson– Weiss syndrome

Joubert syndrome

Juvenile Primary Lateral Sclerosis (JPLS)

Keloid disorder

Kniest dysplasia

Kosaki overgrowth syndrome

Krabbe disease

Kufor–Rakeb syndrome

LCAT deficiency

Lesch-Nyhan syndrome)

Li-Fraumeni syndrome

Lynch Syndrome

Lipoprotein lipase deficiency, familial

Marfan syndrome

Maroteaux–Lamy syndrome

McCune–Albright syndrome

McLeod syndrome

MEDNIK syndrome

Mediterranean fever, familial

Menkes disease

Methemoglobinemia

methylmalonic acidemia

Micro syndrome

Microcephaly

Morquio syndrome

Mowat-Wilson syndrome

Muenke syndrome

Multiple endocrine neoplasia (type 1 and type 2)

Muscular dystrophy

Muscular dystrophy, Duchenne and Becker type

Myostatin-related muscle hypertrophy

myotonic dystrophy

Natowicz syndrome

Neurofibromatosis type I

Neurofibromatosis type II

Niemann–Pick disease

Nonketotic hyperglycinemia

nonsyndromic deafness

Noonan syndrome

Ogden syndrome

osteogenesis imperfecta

Pantothenate kinase-associated neurodegeneration

Patau Syndrome (Trisomy 13)

PCC deficiency (propionic acidemia)

Porphyria cutanea tarda (PCT)

Pendred syndrome

Peutz-Jeghers syndrome

Pfeiffer syndrome

phenylketonuria

Pitt–Hopkins syndrome

Polycystic kidney disease

Polycystic Ovarian Syndrome (PCOS)

porphyria

Prader-Willi syndrome

Primary ciliary dyskinesia (PCD)

primary pulmonary hypertension

protein C deficiency

protein S deficiency

Pseudo-Gaucher disease

Pseudoxanthoma elasticum

Retinitis pigmentosa

Rett syndrome

Rubinstein-Taybi syndrome (RSTS)

Sandhoff disease

Sanfilippo syndrome

Schwartz–Jampel syndrome

spondyloepiphyseal dysplasia congenita (SED)

Shprintzen–Goldberg syndrome FBN1

sickle cell anemia

Siderius X-linked mental retardation syndrome

Sideroblastic anemia

Sly syndrome

Smith-Lemli-Opitz syndrome

Smith Magenis Syndrome

Spinal muscular atrophy

Spinocerebellar ataxia (types 1-29)

SSB syndrome (SADDAN)

Stargardt disease (macular degeneration)

Stickler syndrome

Strudwick syndrome (spondyloepimetaphyseal dysplasia, Strudwick type)

Tay-Sachs disease

tetrahydrobiopterin deficiency

thanatophoric dysplasia

Treacher Collins syndrome

Tuberous Sclerosis Complex (TSC)

Turner syndrome

Usher syndrome

Variegate porphyria

von Hippel-Lindau disease

Waardenburg syndrome

Weissenbacher-Zweymüller syndrome

Williams Syndrome

Wilson disease

Woodhouse–Sakati syndrome

Wolf–Hirschhorn syndrome

Xeroderma pigmentosum

X-linked mental retardation and macroorchidism (fragile X syndrome)

X-linked spinal-bulbar muscle atrophy (spinal and bulbar muscular atrophy)

Xp11.22 deletion

X-linked severe combined immunodeficiency (X-SCID)

X-linked sideroblastic anemia (XLSA)

47,XXX (triple X syndrome)

XXXX syndrome (48, XXXX)

XXXXX syndrome (49, XXXXX)

XYY syndrome (47,XYY)

Modern synthesis

Four processes

Selection

Dominance

Epistasis

Mutation

Genetic drift

Gene flow

Horizontal gene transfer

Linkage

Applications

Explaining levels of genetic variation

Detecting selection

Demographic inference

Evolution of genetic systems

Quantitative genetics

Genetic epidemiology

Statistical genetics

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Research Topics in Biotechnology

Research in the elimination of biohazards has great potential as a productive field of research.

Difference Between Recombinant DNA & Genetic Engineering

Biochemists and other research scientists who work in the field of biotechnology can expect better than average job growth between 2008 and 2018, according to projections by the U.S. Bureau of Labor Statistics. Most of the work in this field is research-oriented and requires advanced degrees like a Ph.D. for employment. Finding the right research topic for a dissertation or research project can be done by simply looking at the major research trends in the field and developing your own niche within one of those research fields.

Pharmacogenetics and Pharmacogenomics

The closely related fields of pharmacogenetics and pharmacogenomics are sub-fields within biotechnology that can yield fruitful results in biotechnology research. Pharmacogenetics explores the relationship between a person's genetic make-up and the way that this influences responses to various types of medicine. Research in this field, as suggested by the Organisation for Economic Co-operation (OEC), can focus on ways to use this knowledge for the purpose of improving public health and health policy. Pharmacogenomics is similar to pharmacogenetics, except that it focuses on the creation of new drugs using biotechnology.

Agro-Biotechnology Research

The Institute of Biotechnology and Genetic Engineering suggests the field of agro-biotechnology for research as well. The Institute's research has focused on the study of medicinal plants and herbs. Types of research experiments can include studies in the rapid production (micropropagation) of genetically engineered plants and herbs that are used for medicinal purposes. The consequences for this type of research can be significant because the end result of the research could be the discovery of ways to genetically engineer and mass produce new plants and herbs that have medical uses.

Food Biotechnology Research

Another research field covered by the Institute is in the area of food biotechnology. This field is another that can have important implications for the entire human population. Food biotechnology research, according to the University of California at Davis, is the production of new plants and animals through genetic engineering for the purpose of food production. Genetic research in this field can involve the use of recombinant DNA (rDNA), a technique whereby scientists remove the genes that produce desirable traits in one species to another species, thereby fusing their genetic sequencing and producing entirely new species. Research in this field can produce nearly limitless results.

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Organisation for Economic Co-Operation and Development: Pharmacogenetics: Opportunities and Challenges for Health Innovation

About the Author

Jared Lewis is a professor of history, philosophy and the humanities. He has taught various courses in these fields since 2001. A former licensed financial adviser, he now works as a writer and has published numerous articles on education and business. He holds a bachelor's degree in history, a master's degree in theology and has completed doctoral work in American history.

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Hot Research Topics in Biotech in 2022

The past few years years have seen leaps and strides of innovation as scientists have worked to develop and produce new mRNA vaccinations and made major developments in biotech research. During this time, they’ve also faced challenges. Ongoing supply chain disruptions , the Great Resignation, and the pandemic have impacted biotech labs and researchers greatly, forcing lab managers and PIs to get creative with lab supply purchasing, experiment planning, and the use of technology in order to maintain their research schedules.

“The pace of innovation specific to COVID to be able to develop both medicines related to antibodies as well as vaccines is just staggering. Those of us in the industry are in awe of the innovation we’re witnessing on a daily basis. We’ve been behind in the use of automation, software, and AI that can make our industry more efficient — that’s where we’re headed,” says Michelle Dipp, Cofounder and Managing Partner, Biospring Partners on the This is ZAGENO podcast .

At the start of 2022, current biotech research projects are exploring advancements in medicine, vaccines, the human body and treatment of disease, bacteria and immunology, and viruses like the Coronavirus that affected the globe in ways we couldn’t have anticipated.

Biotech Research Processes are Changing

As Michelle explained, the research that’s happening is changing, and so is the way that scientists conduct it. Influenced by both B2C ecommerce and the growing dependence on remote and cloud-based working, biotech labs are undergoing digital transformations . This means more software, AI, and automation in the lab, along with modern digital procurement strategies and integrated systems for lab operations.

Here are some of the top biotech research trends and recent biotech research papers that are changing the world of science and leading to innovation in life sciences.

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Biomedical Engineering Research Topics

Basic biomedical dissertation topics, hot topics in biomedical research, good biomedical dissertation topics, latest biomedical science dissertation topics, biomedical ethics topics, biomedical science topics, biomedical engineering topics for presentation, topics for technology in biomedical science, biomedical science dissertation ideas for nanotechnology.

A scholar of biomedical science get dissertation papers to write throughout their course. Now, writing a lengthy document is not accessible to all students. They may need more writing ability and research and management skills to create a solid biomedical science dissertation. So, you must follow specific tips to write it well. First of all, you must find suitable biomedical science dissertation topics. Then, you should research well and create a proper dissertation. Today, you will get some help finding proper biomedical science dissertation ideas here. Read on to know more-

A Brief Overview of Biomedical

Biomedical science, a division of science dedicated to treating a person's physical health, plays a crucial role of biomedical dissertation in students' lives. It's not just about writing a paper but about improving your research skills and gaining in-depth knowledge about the subject. A biomedical science dissertation is your gateway to understanding topics thoroughly and gaining enough insight to contribute to the prevention and treatment of diseases. Let's explore some biomedical science dissertation ideas to inspire you to write a remarkable dissertation. Apart from this, if you face issues with any other subject or paper for example for nursing, you can seek nursing dissertation help from us. But, now let's explore the examples.

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List of 100+ Subject Wise Biomedical Dissertation Topics

So far, you've gained some insights into biomedical science. However, writing a biomedical science dissertation is a unique journey. It's an opportunity to delve deeper into a specific area of interest and contribute to the field. You'll need suitable biomedical engineering topics for a strong dissertation. Here, we've divided the topics into different categories to help you navigate your research. However, if you still face any issues with the dissertation examples , do not hesitate to ask us for the same. Let's embark on this exciting journey of exploration through this biomedical science examples.

1. How can in-depth learning in biomedical engineering be applied?

2. What is the relevance of medical engineering in modern times?

3. Discuss about the latest discoveries and applications in Bionics

4. What are the techniques of genetic engineering?

5. The effects of environmental engineering on the modern world

6. Latest research and solutions in the treatment of cancer

7. Tips to use biotechnology for better results in medical science

8. What are the symptoms of blood cancer that go unnoticed till the last stage?

9. Discuss the research that is required to make humankind free of disease in future

10. Should the use of harmful X-rays be stopped in medical science?

11. How does biotechnology help the growth of medical science?

12. The recent development in biomedical science and treatment of a patient

13. How does biotechnology help in making healthcare services cheaper?

14. Discuss the dark sides of biotechnology for biomedical science

15. What are the roles of biotechnological principles for making more vital vaccines?

16. Ten things to know about artificial womb

17. An introduction of artificial blood and its impact on the health sector

18. How has synthetic biology impacted the revolution of vaccine technology?

19. Gene editing for gene therapy- things you must know

20. The latest discoveries in neural engineering

21. Immunology and its relevance in the modern world

22. Vaccine development for Covid-19

23. What are some myths about antibiotic resistance?

24. Infectious diseases- Now and before

25. Discussion on the regenerative medicines and their importance

26. The relationship between immunology and infection

27. Investigating the mechanisms of ageing

28. How does the gut microbiome perform in autoimmune diseases?

29. The connection between neuroscience and neurobiology

30. The connection between pharmacology and therapeutics

31. Discussion on gene-editing and CRISPR Technology

32. Efficacy of Pembrolizumab in metastatic melanoma treatment

33. Impact of continuous glucose monitoring for those who have Type 1 diabetes

34. Mechanisms of bacterial resistance to colistin

35. Efficiency of pembrolizumab in treating metastatic melanoma

36. The use of pluripotent stem cells for regenerating cardiac tissue

37. The effect of the aggression of Tau Protein in the progression of Alzheimer's Disease

38. The role of PCSK9 inhibitors in reducing LDL cholesterol

39. Bioprinting of vascularized liver tissues

40. A discussion on the development of an influenza virus universally

41. The role of mRNA vaccines in preventing infectious diseases

42. The impact of microbiome engineering on inflammatory bowel disease

43. The use of AI in predicting the outbreak of diseases

44. How is single-cell RNA sequencing used to understand cancer heterogeneity?

45. Development of organ-on-chip models for personalized medicine

46. How does a machine-learning algorithm help to detect the early stage of Alzheimer's?

47. Discuss the role of exosomes in intercellular communication and cancer metastasis

48. The role of metabolomic profiling in detecting pancreatic cancer at early stage

49. What are the impacts of climate change on vector-borne disease transmission?

50. Gene therapy for haemophilia: safety and long-term efficacy

51. The fundamental relationship between a physician and a patient

52. The allocation and distribution of resources

53. Tips to handle disability issues in a healthcare sector

54. Ethical treatment of subjects or animals in clinical trials

55. All you need to know about coercion, consent, and or vulnerability

56. The impact of biobanking on patient autonomy and privacy

57. The moral implications of using embryonic stem cells for research

58. The ethics of organ transplantation and allocation of scarce resources

59. Ethical issues in end-of-life care and physician-assisted suicide

60. Ethical challenges in the development and distribution of vaccines

61. The role of biomechanics in healthcare delivery

62. The latest discoveries in neural engineering

63. What is the importance of biomaterials and regeneration engineering?

64. The evolution of medical instrumentation and devices

65. Analyze the application of cell and molecular engineering to medicine.

66. Discuss the history of digital signals, image processing, and biomedical applications.

67. Describe the role of logarithm-based image processing techniques in biomedical applications.

68. How a Java-based software package is used in biomedical images and volume processing

69. How can a Health Technology Assessment and Management Course in an Undergraduate Program for Biomedical Engineering be implemented?

70. The impact of including health technology assessment subjects in the curriculum of biomedical engineering

71. The implementation of magnetic navigated catheterization

72. The basis of its operation: In-the-ear device to control stuttering

73. The benefits of sensitive artificial skin for prosthetic limbs

74. Semiconductor cell interfaces: the rudiments of its application

75. The benefits of tissue engineering of muscle

76. Advances in 3D bioprinting for tissue engineering and organ regeneration

77. Design and optimization of bioartificial organs

78. The role of biomaterials in regenerative medicine

79. Innovations in implantable medical devices and prosthetics

The impact of robotic surgery on patient outcomes and healthcare

80. Discussion on including health technology assessment subjects in biomedical science

81. The role of wearable technology in health monitoring continuously

82. Application of blockchain technology in securing patient data and medical records

83. Invention of robotic-based surgery and its benefits

84. Advancement of telemedicine and remote patient monitoring

85. The role of big data analytics in personalized medicine

86. Development of smart prosthetics with sensory feedback

87. The impact of bioinformatics in genomics and proteomics research

88. Tissue engineering and regenerative medicines using 3D bioprinting

89. The integration of IoT in healthcare for innovative medical devices

90. The uses of functional particles and nanomaterials

91. Nanostructured materials for biological sensing

92. Nanoparticles-based drug delivery system

93. Nanocrystals- imaging, transportation, and toxicity features

94. Discuss about the insertion of nanoporous membranes into biomedical devices

95. The role of quantum dots for advanced biomedical imaging

96. The impact of liposomal nanoparticles for targeted drug delivery in chemotherapy

97. Carbon nanotubes for neural tissue engineering

98. Nanoparticle-based vaccines for enhanced immune response

99. Nanoscale biosensors for early detection of sepsis

So, here you get several biomedical science thesis topics. These will help you write a constructive biomedical dissertation to submit to your institution. If you need clarification, you can always buy dissertation and save your time and effort.

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Role of HO-1, microRNAs and angiogenesis in Duchenne muscular dystrophy.
Stem cell differentiation and reprogramming.
Induced pluripotent stem cells – generation and differentiation.
Plasmid and viral vectors – construction and validation in experimental gene therapy.
Role of oxidative stress in regulation of gene expression in endothelial cells, progenitor cells and tumor cells.
Role of heme oxygenase-1 in angiogenesis, vasculogenesis, resistance of cancer cells to therapy; role of heme oxygenase-1 in wound healing.
Gene and cell therapy for treatment of cardiovascular disorders.

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Techniques – cell culture and molecular biology techniques.
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Biotechnology Research Topics

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What is Biotechnology?

What first pops up in your mind when you hear the term Biotechnology? Maybe you started thinking of GMOs ( Genetically Modified Organisms ), transgenic cloning, and other gene therapies. Of course, you got it right, but the horizon of biotechnology is not so tiny. It has a wide range of applications in the industry that can improve our living standards. Let us first understand the term Biotechnology. In simple words, it is the utilization of living organisms or their components in the industrial sector to generate various products that are beneficial for the human race. We have been utilizing microorganisms for more than thousands of years to develop useful commodities such as cheese, bread, and various other dairy-related products. Even its implementation in the medical sector has led to the manufacturing of different vaccines, biofuel, chitosan-coated dressing for wounds, brewing, and even age-defying products. As the biotechnology scope is expanding day by day, researchers felt an urge to classify main areas and types of biotechnology depending on some commonalities and their ultimate objectives:

Red Biotechnology- involves the utilization of organisms for upgrading the quality of health care departments and aiding the body’s immune system to fight against various diseases. Examples include; the development of different vaccines, antibiotics, medicinal drugs, and various molecular techniques.

White Biotechnology- mainly comprises industrial biotechnology and involves the utilization of microorganisms and their by-products for manufacturing more eco-friendly and energy-efficient products. White biotechnology examples include the production of biofuel, Lactic acid, and 3- hydroxy propionic acid.

Yellow Biotechnology- it is related to the use of Biotech in the food production area, i.e., making bread, cheese, beer, and wine by the fermentation process.

Grey Biotechnology – mainly deals with the removal of pollutants from the environment by using various microorganisms and plants. For example., different strains of bacteria can be used for the degradation of kitchen waste into compost.

Green Biotechnology- concentrates on the agriculture sector and focuses on generating new varieties of plants and producing good quality bio-pesticides & bio-fertilizers.

Blue Biotechnology – it mainly refers to the utilization of aquatic or marine organisms to create goods that can aid various industrial processes, such as using Chitosan (sugar derived from the shells of crabs and shrimps) for the dressing of wounds.

Biotechnology Topics for Research Paper

In the modern world, students are apprehending the benefits of Biotech and want to study it with more enthusiasm and interest. They are actively opting for this subject and compiling their research work to contribute their efforts in the field of Biotechnology. They are indulged in exhaustive research to find the best topic for the research purpose. So, here are a few potential research topics in the domain of Biotechnology:

Red Biotechnology Research Topics:

Studying the relationship between the intake of iron-folic acid during pregnancy and its impact on the overall health of the fetus.
Pharmacogenomics of antimicrobial drugs.
Identifying the biomarkers linked with breast cancer.
Study the medicinal value of natural antioxidants.
Study the structure of coronavirus spike proteins.
Studying the immune response of stem cell therapy.
Utilization of CRISPR-Cas9 technology for genome editing.
Application of Chitosan in tissue engineering and drug delivery.
Study the therapeutic effects of cancer vaccines.
Utilizing PacBio sequencing for the genome assembly of model organisms.
Study the relationship between the suppression of mRNA and its effect on stem cell expansion.
Study the application of nanoprobes in molecular imaging.
Incorporating biomimicry for the detection of tumor cells.
Study of immune-based therapies in treating COVID-19.
Regulation of immune response using the cellular and molecular mechanism
Microchip implantation – a vaccine for coronavirus.
The Use of CRISPR for Human Genome Editing

Yellow Biotechnology Research Topics:

Production of hypoallergenic milk.
Production of hypoallergenic fermented foods.
Yellow enzymes subclassification and their characterization.

White Biotechnology Research Topics:

Bioconversion of cellulose to yield industrially important products.
Studying the inhibitors of endocellulase and exocellulase.
Fungal enzymes used in the production of chemical glue.
Mechanism of fungal enzymes in the biodegradation of lignin.
Studying gut microbiota in model organisms.
Study the lactic acid bacteria for probiotic potential.
Purification of thermostable phytase.
Mesophilic and Thermophilic aerobic and anaerobic bacteria from compost.
Study the dietary strategies for the prophylaxis of Alzheimer’s and dementia.
Examine the positive effects of probiotics and prebiotics on the nervous system.

Examples of Grey Biotechnology Research Topics:

Production of sustainable, low-cost, and environmentally friendly microbial biocement and biogrouts.
Use of microorganisms for the recovery of shale gas.
Studying the procedure of natural decomposition.
Treatment of grey water in a multilayer reactor with passive aeration.
Excavation of various anaerobic microbes using grey biotechnology.
Improving the biodegradation of micro-plastics using GMOs.
Removal of pollutants from the land.
Use of microbes to excavate the hidden metals from earth.
Managing the processes of environmental biotechnology using microbial ecology.
In situ product removal techniques using the process of biocatalysis.
Production of biodegradable, disposable plastic for the storage of food.
Plastic waste decomposition management.
Maintaining a healthy equilibrium between biotic and abiotic factors using biotechnological tools.
Recycling of biowastes.
Restoration of biodiversity using tools.
Improved Recombinant DNA technology for bioremediation.
Gold biosorption using cyanobacterium.
Improved bioremediation of oil spills.
Biodegradation of oil and natural gas.

Blue Biotechnology Research Ideas:

Various bioactive compounds derived from marine sponges.
Controlling the emerged biological contaminant using the sustainable future.
Protecting the environment using grey, blue, and green biotechnology.
Exploring marine biota which survives the extreme conditions.
Studying the patterns of Arctic and Antarctic microbiota for the benefits of humans.
Excavation of bioactive molecules from extreme environmental conditions.
Studying the potential of sponge-associated microbes.
Mercury labeling in the fish using markers.
Sea urchin repelling ocean macroalgal afforestation.
Microbial detection techniques to find sea animals.
Studying the mechanisms in deep-sea hydrothermal vent bacteria.
Production of antibiotics using marine fungi.
Exploring the biotechnological potential of Jellyfish associated microbiome.
Exploring the potential of marine fungi in degrading plastics and polymers.
Expl oring the biotechnological potential of dinoflagellates.

Green Biotechnology Research Paper Topics:

Detection of endosulfan residues using biotechnology in agricultural products.
Development of ELISA technique for the detection of crops’ viruses.
Use of Green Fluorescent Protein (GFP) as a cytoplasmic folding reporter.
E.coli as an all-rounder in biotechnological studies.
Improving the water quality for drinking using E.coli consortium.
E.coli characterization isolated from the zoo animals’ feces.
Biocatalysis and agricultural biotechnology in situ studies.
Improving the insect resistance of the crops.
Improving the nutritional value and longer shelf life of GM crops.
Improving the qualities of hydroponic GM plants.
Reducing the cost of agriculture using bio-tools.
Production of heavy cotton balls in agricultural biotechnology using in situ technique.
Steps to minimize soil erosion using the tools of biotechnology.
Enhancement of vitamin levels in GM Foods .
Improving pesticide delivery using biotechnology.
Comparison of folate biofortification of different crops.
Photovoltaic-based production of crops in the ocean.
Application of nanotechnology in the agricultural sector.
Study the water stress tolerance mechanisms in model plants.

Combination and Analytical Topics:

Sequencing of infectious microbes using molecular probes.
Production and testing of human immune boosters in experimental organisms.
Comparative genomic analysis using the tools of bioinformatics.
Arabinogalactan protein sequencing using computational methods.
Comparative analysis of different protein purification techniques.
Oligonucleotide microarrays used in the diagnosis of the microbes.
Uses of different techniques in biomedical research including microarray technology.
Microbial consortium used to produce the greenhouse effect.
Computational analysis of different proteins obtained from marine microbiota.
Gene mapping of E.coli using different microbial tools.
Computational analysis and characterization of the crystallized proteins in nature.
Improving the strains of cyanobacterium using gene sequencing.
mTERF protein used to terminate the mitochondrial DNA transcription in algae.
Reverse phase column chromatography used to separate proteins.
Study of different proteins present in Mycobacterium leprae.
Study the strategies best suitable for cloning RNA
Study the application of nanocarriers for the gene expression in model plants.
Exploring thermotolerant microorganisms for their biotechnological potential.

Biotechnology is full of research prospects. Various research and development companies are working day and night to achieve the required outcomes for different branches of biotechnology. If you find these list of Biotechnology research topics helpful, you may visit our blog for further assistance.

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Health systems management and health sector reform

Performance-Based Payments, Provider Motivation and Quality of Care in Afghanistan
Health Systems Strengthening in Post-Conflict Settings: Employee and Patient Satisfaction in Hospitals in Afghanistan
The Use of Clinical Practice Guidelines to Improve Provider Performance of Well-Child Care in Armenia
Quality Improvement and Its Effect on Patient Perceptions and Demand for Health Services-Evidence from Uttar Pradesh, India
The Perception of Quality Among Users of Commune Health Centers and Users of Private Providers in Northern Vietnam

Health financing

National Health Insurance in Ghana: Politics, Adverse Selection, and the Use of Child Health Services.
Evaluating the Effectiveness of User Fee Increase in Improving The Quality of Care: Government Primary Health Care Services in Indonesia
The Impact of Community-Based Health Insurance on Health Care Utilization and Financial Sustainability: The Example of Rwanda
Impact of Health Insurance on Health Care Utilization in Vietnam
Stimulating Demand: An Assessment of the Conditional Cash Transfer Project in Afghanistan

Health policy and resource allocation

Exploring Attitudes and Perceptions of Policymakers and Health Researchers Towards Evidence-Based Health Policymaking in Argentina: A Mixed Methods Approach
Dual Practice in Kampala, Uganda: A Mixed Methods Study of Management and Policy
Understanding Political Priority Development for Public Health Issues in Turkey: Lessons from Tobacco Control & Road Safety
Academic Knowledge Brokers in Kenya: A Mixed Methods Study of Relationships, Characteristics and Strategies
Decision-Making for Allocation of Public Resources in Decentralized District Health Systems in Uganda

Maternal, neonatal and child health

Antenatal and Delivery Care in Afghanistan Knowledge and Perceptions of Services, Decision Making for Service Use, and Determinants of Utilization
Early Maternal Morbidity and Utilization of Delivery Services by Urban Slum Women of Dhaka, Bangladesh
An Assessment of Maternal Health Service Needs of Immigrant Women Living in East Calgary, Canada
Health Seeking Behavior of Women and Their Families During Pregnancy, Delivery and Postpartum Period in Nepal

Evaluation of health programs

Comparison of Biomarker Surveillance of Measles Immunity to Conventional Indicators of Vaccination Coverage
Qualitative Research to Develop a Framework for Evaluating the Sustainability of Community-Based Child Health Programs Implemented by Non-Government Organizations
Evaluating the Delivery Huts Program for Promoting Maternal Health in Haryana, India
Evaluating the Scale-Up of Community Case Management in Malawi: Health System Supports, Health Worker Attitudes, and Equity of Service Provision

Refugee and humanitarian assistance

Family Relationships and Social Interaction in Post-Conflict South Kivu Province, Eastern Democratic Republic of Congo A Mixed Methods Study with Women from Rural Walungu Territory
Utilization of Health Services for Children after the Tsunami in Aceh, Indonesia
Factors Affecting School Enrollments in a Post-Repatriation Context: A Study of Household Roles, Attitudes and Forced Migration Processes in Urban Somaliland
A Balanced Scorecard for Assessing the Quality and Provision of Health Services in UNHCR Refugee Camps

Injury prevention and control

Road Traffic Injuries In China: Time Trends, Risk Factors and Economic Development
Evaluating an Intervention to Prevent Motorcycle Injuries in Malaysia: Process Performance, and Policy
Injuries and Socioeconomic Status in Iganga and Mayuge, Uganda: Inequities, Consequences and Impacts
A neglected epidemic of childhood drowning in Bangladesh: Epidemiology, risk factors and potential interventions

Equity and fairness in distribution of health services

Gender and Access to DOTS Program (Directly Observed Treatment, Short-Course) in a Poor, Rural and Minority Area of Gansu Province, China
Empowering the Socially Excluded: A Study of Impact on Equity by Gender, Caste and Wealth in Access to Health Care in Rural Parts of Four North Indian States
Gender, Empowerment, and Women's Health in India: Perceived Morbidity and Treatment-Seeking Behaviors for Symptoms of Reproductive Tract Infections among Women of Rural Gujarat
Trust in Maternity Care: A Contextual Exploration of Meaning and Determinants in Peri-Urban Kenya
The Effect of Contracting for Health Services on the Equity of Utilization and Out-of-Pocket Health Expenditure in Rural Afghanistan

Health economics

The Equity and Cost-Effectiveness of HIV Voluntary Counseling and Testing in Tanzania
Hospital Coding Practice, Data Quality, And DRG-Based Reimbursement Under the Thai Universal Coverage Scheme
Willingness-to-Pay and Cost-Benefit Analysis on Introducing HIB Conjugate Vaccine into the Thai Expanded Program on Immunization
Economic Evaluation of the Costs and Cost-Effectiveness of the Diarrhea Alleviation through Zinc and Oral Rehydration Therapy Program at Scale in Gujarat, India
The Economics of Non-Communicable Diseases in Rural Bangladesh: Understanding Education Gradients in Mortality and Household Wealth Impacts from an Adult Death

Health outcomes and burden of disease methods

Measuring the Burden of Disease: Introducing Healthy Life Years
Measuring the Burden of Injuries in Pakistan Epidemiological and Policy Analysis
Strengths and Limitations of Population-Based Health Surveys in Developing Countries: A Case Study of National Health Survey of Pakistan: 1990-94
Approaches to Measuring Non-Fatal Health Outcomes: Disability at the Iganga-Mayuge Demographic Surveillance System in Uganda
A National Burden of Disease Study for The United Arab Emirates (UAE): Quantifying Health Differentials Between Nationals and Migrants

Bibliography
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200+ Biotechnology Research Topics: Let's Shape the Future
Biotechnology, at its core, involves the application of biological systems, organisms, or derivatives to develop technologies and products for the benefit of humanity. The scope of biotechnology research is broad, covering areas such as genetic engineering, biomedical engineering, environmental biotechnology, and industrial biotechnology.
Top 100 Biotechnology Dissertation Topics for the Year 2021
So, let us begin with the prepared list of topics one by one -. Effective management of renewable energy technology to promote a village. The production of ethanol with the help of molasses as well as its effluent treatment. Different methods and aspects of evapotranspiration.
Top 50 Emerging Research Topics in Biotechnology
Biotechnology is a dynamic field that continuously shapes our world, enabling innovation, breakthroughs, and solutions to various challenges. As we move into the future, numerous emerging research areas promise to revolutionize healthcare, agriculture, environmental sustainability, and more. The top 50 emerging research topics in biotechnology are presented in this article.
45 Biomedical Research Topics for You
Biomedical research is an extensive process. It requires a lot of time, dedication, and resources. Getting a topic shouldn't be added to that list. There are biomedical thesis topics and research topics in biomedical science for you here: Air pollution- sources, impact, and prevention; Covid-19 vaccination- the effect on life expectancy
Top 50 Research Topics in Biotechnology
Look at some of the top trends in biotech research and recent Biotechnology Topics that are bringing massive changes in this vast world of science, resulting in some innovation in life sciences and biotechnology ideas. Development of vaccine: Development of mRNA has been done since 1989 but has accelerated to combat the pandemic. As per many ...
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If you're just starting out exploring biotechnology-related topics for your dissertation, thesis or research project, you've come to the right place. In this post, we'll help kickstart your research topic ideation process by providing a hearty list of research topics and ideas, including examples from recent studies.. PS - This is just the start…
150 Research Proposal Topics In Biotechnology
Not just in terms of prospects, but also in terms of wage packages for biotechnology experts. Top 150 Research Proposal Topics and more about Biotechnology for 2022 from the best academic expert dissertation writers of AHECounselling. Plant, Pharmacogenetics, Forensic DNA, Food, Proteomics Biotechnology.
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Theses/Dissertations from 2016. PDF. In Vitro and In Vivo Antioxidant Capacity of Synthetic and Natural Polyphenolic Compounds Identified from Strawberry and Fruit Juices, Marvin Abountiolas. PDF. Quantitative Proteomic Investigation of Disease Models of Type 2 Diabetes, Mark Gabriel Athanason. PDF.
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Biotechnology Research Paper Topics. This collection of biotechnology research paper topics provides the list of 10 potential topics for research papers and overviews the history of biotechnology. The term biotechnology came into popular use around 1980 and was understood to mean the industrial use of microorganisms to make goods and services ...
FOCUSED RESEARCH TOPICS
7. Medical genetics: Types of genetic disorder: Single-gene: Autosomal dominant: Autosomal recessive: X-linked dominant: X-linked recessive: Y-linked: Mitochondrial: Causes of genetic disorder: Diagnosis: Treatment / gene therapy: List of genetic disorder: 1p36 deletion syndrome: 18p deletion syndrome: 21-hydroxylase deficiency: Alpha 1 ...
Frontiers in Bioengineering and Biotechnology
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By Jared Lewis. Biochemists and other research scientists who work in the field of biotechnology can expect better than average job growth between 2008 and 2018, according to projections by the U.S. Bureau of Labor Statistics. Most of the work in this field is research-oriented and requires advanced degrees like a Ph.D. for employment.
Current research in biotechnology: Exploring the biotech forefront
Starting in the mid-1980s, biotechnology became a very popular word in the title of research publications, appearing in papers concerning business, industry, biomedicine, chemical engineering, agricultural sciences, and even social sciences (Kennedy, 1991). In short, biotechnology signifies a new biological approach to a wide range of industries.
Hot Research Topics in Biotech in 2022
With new access to data from the 3.4 billion+ COVID-19 mRNA vaccines that have been administered worldwide, researchers have been able to determine the risks associated with mRNA vaccines, which brings forward new topics for research in the medical and pharmaceutical sides of the biotech industry. mRNA vaccines are faster to develop and can ...
Biological Sciences thesis and dissertation collection
Lincoln, Matthew (The University of Edinburgh, 2024-08-12) This study investigates the complex role of HEXOKINASE (HXK) genes, with a focus on HXK1, in Arabidopsis thaliana seedling development and glucose sensing mechanisms. HEXOKINASEs are a family of glucose-phosphorylating ...
Internship/Dissertation Programme
B.Tech. (or) M.Tech. (Biotechnology, Biomedical, Information Technology, Computer Science) Duration of Internship/Dissertation Programme: The dissertation programme will be allowed for a minimum period of 6 months. Internship/Observation visit is permitted for a period of 15 days. Application Procedure:
Dissertations / Theses: 'Medical Biotechnology'
List of dissertations / theses on the topic 'Medical Biotechnology'. Scholarly publications with full text pdf download. Related research topic ideas.
100+ Trending Biomedical Dissertation Topics and Ideas
7. Tips to use biotechnology for better results in medical science. 8. What are the symptoms of blood cancer that go unnoticed till the last stage? 9. Discuss the research that is required to make humankind free of disease in future. 10. Should the use of harmful X-rays be stopped in medical science? Basic Biomedical Dissertation Topics. 11.
Research Areas
However, the MBP ensures that each of the 12 areas of research listed on our website continue to be adequately represented by research projects. Biomaterials. Cancer Biotechnology. Cardiovascular Biology and Transplantation Biology. Cell and Molecular Biology. Developmental Biology and Neurobiology. Diagnostics and Medical Devices.
Master's thesis topics
Master's thesis topics. Role of HO-1, microRNAs and angiogenesis in Duchenne muscular dystrophy. Stem cell differentiation and reprogramming. Induced pluripotent stem cells - generation and differentiation. Plasmid and viral vectors - construction and validation in experimental gene therapy.
100+ Biotechnology Research Topics
Examples of Grey Biotechnology Research Topics: Production of sustainable, low-cost, and environmentally friendly microbial biocement and biogrouts. Use of microorganisms for the recovery of shale gas. Studying the procedure of natural decomposition. Treatment of grey water in a multilayer reactor with passive aeration.
Recent Dissertation Titles
Approaches to Measuring Non-Fatal Health Outcomes: Disability at the Iganga-Mayuge Demographic Surveillance System in Uganda. A National Burden of Disease Study for The United Arab Emirates (UAE): Quantifying Health Differentials Between Nationals and Migrants. Johns Hopkins Bloomberg School of Public Health.
Dissertations / Theses: 'Medical laboratory technology'
Consult the top 46 dissertations / theses for your research on the topic 'Medical laboratory technology.'. Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard ...

200+ Biotechnology Research Topics: Let’s Shape the Future

Overview of Biotechnology Research

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200+ Biotechnology Research Topics: Category-Wise

Biomedical Engineering

Environmental Biotechnology

Industrial Biotechnology

Emerging Trends in Biotechnology

Ethical and Social Implications

Computational Biology and Bioinformatics

Health and Medicine

Agricultural Biotechnology

Biotechnology and Education

Funding and Policy

Biotechnology and the Environment

Biosecurity and Biosafety

Industry Applications

Miscellaneous Topics

Challenges and Ethical Considerations in Biotechnology Research

Funding and Resources for Biotechnology Research

Future Prospects of Biotechnology Research

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Top 50 Emerging Research Topics in Biotechnology

1. Gene Editing and Genomic Engineering

a. CRISPR and Gene Editing

b. Synthetic Biology

2. Personalized Medicine and Pharmacogenomics

a. Precision Medicine

b. Pharmacogenomics

3. Nanobiotechnology and Nanomedicine

a. Nanoparticles in Medicine

b. Nanosensors and Diagnostics

4. Immunotherapy and Vaccine Development

a. Cancer Immunotherapy

b. Vaccine Technology

5. Environmental Biotechnology and Sustainability

a. Bioremediation and Bioenergy

b. Agricultural Biotechnology

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Research Proposal Topics In Biotechnology

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Structural Biology of Infectious Diseases

Plant Biotechnology

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Forensic DNA

Food Biotechnology